A bulge is an extra, unpaired nucleotide on one strand of a DNA double helix. This paper describes bulge-specific strand scission by the DNA intercalating/cleaving drugs neocarzinostatin chromophore (NCS-C), bleomycin (BLM), and methidiumpropyl-EDTA (MPE). For this study we have constructed a series of 5'-32P end labeled oligonucleotide duplexes that are identical except for the location of a b...

We report detailed chemical abundance analysis of 27 RGB stars towards the Galactic bulge in Baade’s Window for elements produced by massive stars: O, Na, Mg, Al, Si, Ca and Ti. All of these elements are overabundant in the bulge relative to the disk, indicating that the bulge is enhanced in Type II supernova ejecta and most likely formed more rapidly than the disk. Our [Mg/Fe] ratios, confirme...

How stem cells maintain their identity and potency as tissues change during growth is not well understood. In mammalian hair, it is unclear how hair follicle stem cells can enter an extended period of quiescence during the resting phase but retain stem cell potential and be subsequently activated for growth. Here, we use lineage tracing and gene expression mapping to show that the Wnt target ge...

WFPC2 images obtained with the Hubble Space telescope 4.16 years apart have allowed us to measure the proper motion of the metal rich globular cluster NGC 6553 with respect to the background bulge stars. With a space velocity of (Π, Θ, W) = (-3.5, 230,-3) km s −1 , NGC 6553 follows the mean rotation of both disk and bulge stars at a Galactocentric distance of 2.7 kpc. While the kinematics of th...

The observed spectra of the microlensed sources towards the Galactic bulge may be used as a tool for studying the kinematics and extinction effects in the Galactic bulge. In this paper, we first investigate the expected distribution of the microlensed sources as a function of depth within the Galactic bulge. Our analysis takes a magnitude limited microlensing survey into account, and includes t...

The currently discussed theories of bulge formation are reviewed, including the pri-mordial scenario, where bulges form rapidly and then accrete disks, the secular scenario, where bulges are formed by dynamical evolution of disks through bars and galaxy interactions , and some combinations of both, where formation of bulges and disks are more continuous and interleaved. The various scenarios ma...

The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re-establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includes specific cell populations within the hair follicle (HF). Under physiological conditions, the epithelial compartments of HF and interfollicular epidermis re...

We report on detailed abundances of giants in the Galactic bulge, measured with the HIRES echelle spectrograph on the 10-m Keck telescope. We also review other work on the bulge field population and globular clusters using Keck/HIRES. Our new spectra have 3 times the resolution and higher S/N than previous spectra obtained with 4m telescopes. We are able to derive log g from Fe II lines and exc...