Worldwide competition among manufacturing enterprises has acted as a driving force for the design, development and utilization of manufacturing systems with an increased degree of agility. In these regards, Holonic Manufacturing Systems (HMS) are considered an intelligent systems paradigm to meet requirements for agile manufacturing systems. Despite all advantages of HMS, design and implementat...

Hydrologic analyses are commonly based on a single conceptual model. Yet hydrologic environments are open and complex, rendering them prone to multiple interpretations and conceptualizations. Considering conceptual model uncertainty is a critical process for the assessment of hydrologic uncertainty. This study assesses recharge and geologic model uncertainty for the Climax Mine area of the Neva...

Telomere length has a biological link to cancer, with excessive telomere shortening leading to genetic instability and resultant malignant transformation. Telomere length is heritable and genetic variants determining telomere length have been identified. Telomere biology has been implicated in the development of hematological malignancies (HMs), therefore, closer examination of telomere length ...

Insulin-like growth factors (IGFs) are important regulators of the activity of mature osteoblasts, but their effects on osteoprogenitor cells in human bone marrow stroma are unclear. In this study, we assessed the effects of IGFs on a conditionally immortalized human marrow stromal cell line, hMS(3-4), which has the ability to differentiate to either mature osteoblasts or adipocytes. hMS(3-4) c...

Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in three murine mutants with distinct naturally occurring mutations in the glycine receptor (GlyR), leads to intrinsic and/or synaptic homeostatic plasticity. Whole cell recordings were obtained from HMs in transverse brai...

Digital hydrologic networks depicting surface-water pathways and their associated drainage catchments provide a key component to hydrologic analysis and modeling. Collectively, they form common spatial units that can be used to frame the descriptions of aquatic and watershed processes. In addition, they provide the ability to simulate and route the movement of water and associated constituents ...

Streamflow estimates are substantially important as fresh water shortages increase in arid and semi-arid regions where evapotranspiration (ET) is a significant contribution to the water balance. In this regard, evapotranspiration data can be assimilated into a distributed hydrological model (SWAT, Soil and Water Assessment Tool) for improving streamflow estimates. The SWAT model has been widely...