The aim of the present work was the development of chitosan ascorbate nanoparticles (CSA NPs) loaded into a fast-dissolving matrix for the delivery of antibiotic drugs in the treatment of atrophic vaginitis. CSA NPs loaded with amoxicillin trihydrate (AX) were obtained by ionotropic gelation in the presence of pentasodium tripolyphosphate (TPP). Different CSA:TPP and CSA:AX weight ratios were c...

Polysaccharides are suitable for application as hydrophilic matrices because of their ability to hydrate and swell upon contact with fluids, forming a gel layer which controls drug release. When extracted from plants, polysaccharides often contain significant quantities of starch that impacts upon their functional properties. This study aimed to evaluate differences in swelling, erosion and dru...

block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. in this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. the factor fphil is defined as the ratio of the number of hydroph...

density (r/g cm-3) and viscosity (h/10-2gcm-1s-1=1centipoise,cp) of guanosine monophosphate (gmp) and adenosine triphosphate (atp) referred to as nucleotide, and 2-deoxy adenosine (doa) and thymidine (tmd) as nucleoside along with their integral furanose sugar, 2-deoxy ribose (dor) from 0.0004 to 0.0014mol kg-1 solution have been measured at 288.15, 293.15 and 298.15k at atmospheric pressure. t...

A straightforward, high-throughput method was developed and fully validated for the simultaneous determination of the specific tobacco biomarkers nicotine and its main metabolite cotinine in a wide dynamic range and supporting the most common human biological matrices (urine, oral fluid and hair). Sample preparation was performed inside the very HPLC injection vials by pipetting 0.5 mL of the l...

AIMS To estimate the contribution of various occlusal features of the natural dentition that may identify self-reported bruxers compared to nonbruxers. METHODS Two age- and sex-matched groups of self-reported bruxers (n = 67) and self-reported nonbruxers (n = 75) took part in the study. For each patient, the following occlusal features were clinically assessed: retruded contact position (RCP)...

We discuss cross-reactions that can occur when a patient allergic to a specific allergen also reacts to a similar allergen. Currently, The American Contact Dermatitis Society Contact Allergy Management Program, which allows physicians to identify safe products for their patients, uses a 10% threshold to distinguish significant cross-reactors. New clinical data from a patch testing center along ...

PURPOSE Deprivation of oxygen to the ocular surface during contact lens wear has been implicated in the alteration of sensory function. This study investigates whether increasing oxygen availability through discontinuation of contact lens wear or transfer into highly oxygen transmissible (high Dk/t) lenses leads to a change in corneal or conjunctival sensitivity. METHODS Twenty-seven long-ter...

The surface parameter of nanoparticles such as hydrophobicity and a hydrophilicity on protein structure and function is very important. In this study, conformational changes of glucose oxidase (GOx) in the mercaptopurine: GNPs and 11-mercaptoundecanoic acid: GNPs as a hydrophobic and a hydrophilic GNPs surface was investigated by various spectroscopic techniques, including: UV-Vis absorption, f...

BACKGROUND The prevalence of contact allergy to fragrance mix (FM) I varies from study to study, depending on factors such as test population, patch test material, and technique. OBJECTIVES To compare the outcome of routine patch testing with FM I TRUE Test and FM I Trolab. MATERIALS AND METHODS A total of 5006 consecutive eczema patients were patch tested with both patch test materials acc...