BACKGROUND Hydroxyethyl starch (HES) is used for fluid replacement in millions of patients around the world every year, yet it has been found to have adverse effects that have a negative impact on patient survival. Recent clinical trials with a modern HES solution (HES 130) and meta-analyses now enable a reassessment of its risks and benefits. METHODS On the basis of a selective literature se...

We read with interest the article by Meybohm and colleagues regarding the use of hydroxyethyl starch (HES) in critically ill patients [1]. Although we may agree with their conclusion that the most important question is whether or not HES may be harmful, we cannot agree with their suggestion on further clinical use based only on strict indication for HES or a safety checklist. In recent major ra...

Hydroxyethyl starch (HES) has found widespread use to increase the efficiency of granulocyte collection. Although there is some concern about the possible harmful side effects on the donor. such as plasma expansion. these are believed to be shortlived. since the hematocrit returns to baseline by 24 hr. We have used ‘31l-albumin to measure the actual changes in plasma volume in donors who receiv...

Hydrogel systems based on hydroxyethyl starch-polyethylene glycol methacrylate (HES-P(EG)(6)MA) or hydroxyethyl starch methacrylate (HES-MA) were used to assess the protein release behavior. Here, we analyzed the in vitro release of FITC-anti-human antibodies incorporated in either HES-P(EG)(6)MA or HES-MA hydrogel delivery systems in PBS or human serum. In addition, hydrogel disks and micropar...

117 RefeRences 1. Ma PL, Peng XX, Du B, Hu XL, Gong YC, Wang Y, et al. Sources of heterogeneity in trials reporting hydroxyethyl starch 130/0.4 or 0.42 associated excess mortality in septic patients: A systematic review and meta‐regression. Chin Med J 2015;128:2374‐82. doi: 10.4103/0366‐ 6999.163387. 2. Zhu GC, Quan ZY, Shao YS, Zhao JG, Zhang YT. The study of hypertonic saline and hydroxyethyl...