Clioquinol, an 8-hydroxyquinoline derivative (5-chloro-7-iodo-8-hydroxyquinoline) with antimicrobial properties, has recently been found to have cytotoxic activity towards human cancer cell lines at concentrations achieved by oral administration. This study was initiated to determine whether clioquinol could potentiate the antitumor effects of two drugs, doxorubicin and docosahexaenoic acid (DH...

A ditopic DTPA monoamide derivative containing an 8-hydroxyquinoline moiety was synthesized and the corresponding gadolinium(III) complex ([Gd(H5)(H(2)O)](-)) was prepared. After adding aluminum(III), the 8-hydroxyquinoline part self-assembled into a heteropolymetallic triscomplex [(Gd5)(3)Al(H(2)O)(3)](3-). The magnetic and optical properties of this metallostar compound were investigated in o...

A very simple, ultra-sensitive and highly selective non-extractive spectrophotometric method for the determination of trace amount of molybdenum(VI) using 5,7-dibromo-8-hydroxyquinoline (DBHQ) has been developed. 5,7-Dibromo-8-hydroxyquinoline reacts in a slightly acidic solution (0.05 - 1.0 M H2SO4) with molybdenum(VI) to give a deep greenish-yellow chelate which has an absorption maximum at 4...

The concept of detection limit was combined with quantum chemical calculations for trace analysis cadmium and lead in aqueous solution using deprotonated 8-hydroxyquinoline (oxine) as ligand. DFT study performed 6-31G(d), cc-pVTZ SDD basis sets combination different theoretical methods such as; B3LYP, MP2 M06L implemented Gaussian 09 program package. obtained results the gas phases show that st...

A simple and efficient protocol for the synthesis of previously unknown 2-(2-(4-methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic acid was elaborated. The suggested method is based on telescoped multicomponent reaction 8-hydroxyquinoline, 4-methylglyoxal, Meldrum’s acid. studied process includes initial interaction starting compounds in MeCN followed by intramolecular cyclization to target product ...