ost of the previous observational studies suggest that estrogen replacement therapy reduces cardiovascular risks,1 but meta-analysis of randomized clinical trials showed increased risk of hormone replacement therapy for cardiovascular events.2 Both hypercoagulability and upregulation of inflammation-sensitive proteins could underline the increased risk of estrogen treatment in coronary artery d...

Introduction Case Physiology of Hemostasis Vasoconstriction Primary Hemostasis Platelet Adhesion Platelet Granule Release Reaction Platelet Aggregation and Consolidation Secondary Hemostasis: The Coagulation Cascade Regulation of Hemostasis Pathogenesis of Thrombosis Endothelial Injury Abnormal Blood Flow Hypercoagulability Pharmacologic Classes and Agents Antiplatelet Agents Cyclooxygenase Inh...

We evaluated factor IX activation peptide and soluble adhesion molecules of the selectin class (endothelial, leukocyte and platelet) in a group of patients affected by chronic myeloproliferative disorders (essential thrombocythemia and polycythemia vera) with high platelet counts in a stable condition. Using these markers, we could not demonstrate evidence of hypercoagulability or endothelial d...

Arterial embolism with lower limb ischemia is a rare manifestation of paraneoplastic hypercoagulability in cancer patients. We report a unique case of fatal thromboembolism involving both circulations associated with a poorly differentiated neuroendocrine tumor of the lung with rapid progress despite high doses of unfractioned heparin and review the current literature on anticoagulative regimen...