REPRINTED WITH PERMISSION • AUTISM SCIENCE DIGEST: THE JOURNAL OF AUTISMONE • ISSUE 04 audiTory hypersensiTiviTy and auTism specTrum disorders One concern parents and professionals may have with children who have been diagnosed with an autism spectrum disorder (ASD) is that some of these children cannot tolerate listening to certain sounds. Often, parents observe that the children put their han...

Purpose To provide information on the type of "hypersensitivity-friendly" components available for primary total knee arthroplasty (TKA) in the current market. Materials and Methods Implant manufactures were identified using the 2013 National Joint Registries of the United Kingdom and Sweden and contacted to obtain information about the products they offer for patients with metal hypersensiti...

BACKGROUND Food hypersensitivity is commonly suspected, but seldom verified. Patients with subjective food hypersensitivity suffer from both intestinal and extraintestinal health complaints. Abnormalities of the enterochromaffin cells may play a role in the pathogenesis. The aim of this study was to investigate enterochromaffin cell function in patients with subjective food hypersensitivity by ...

Although formaldehyde is well known to cause type 4 hypersensitivity, immunoglobulin E (IgE)-mediated hypersensitivity to formaldehyde is rare. Here, we report a case of recurrent generalized urticaria after endodontic treatment using a para-formaldehyde (PFA)-containing root canal sealant and present a review of previous studies describing cases of immediate hypersensitivity reactions to forma...

Anticonvulsants have long been recognized as a cause of hypersensitivity reactions. Phenytoin hypersensitivity can be traced to 1916, when phenylethylhydantoin (phenytoin sodium), which was used to treat children with Sydenham chorea, was found to induce a hypersensitivity reaction. Phenytoin was then known as a “nerve sedative,” and the hypersensitivity reaction, “nirvanol sickness,” resolved ...

Drug hypersensitivity is a common and complicated problem in clinical practice. The clinical picture of drug hypersensitivity is very heterogeneous, encompassing such distinct diseases as morbilliform or bullous exanthema, urticaria, anaphylaxis, blood cell dyscrasia, fever, interstitial lung disease, hepatitis, nephritis, and various forms of autoimmune diseases. Drug hypersensitivity has take...

BACKGROUND Although evidence points to a role for histamine and serotonin in visceral hypersensitivity, activation of calcium channels such as transient receptor potential vanilloid 4 (TRPV4) also causes visceral hypersensitivity. We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating histamine- and serotonin-induced visceral hypersensitivity. METHODS In res...

We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combination chemotherapy regimen at a single hospital between January 2006 and Decemb...

Exposure to compounds of beryllium can cause dermatitis, acute pneumonitis and chronic pulmonary granulomatosis ("berylliosis") in humans. These syndromes seem to have an allergic-immunologic component in common. Hypersensitivity to beryllium is of the delayed (cell-mediated) type and can be measured as skin reactivity to patch test; lymphocyte blast transformation; and macrophage migration inh...

background: various compounds of plant origin have been widely investigated since ancient times for their possible immunomodulatory properties as well as for the treatment of a wide range of diseases. objective: to study the immunomodulatory functions of the aqueous extract of the seeds of abrus precatorius commonly known as indian liquorice (fabaceae), a medicinal plant native to central india...