Diabetes Mellitus (DM) is recognized as a critical priority because of its epidemic nature. Successful diabetes treatment not yet established and nowadays, considered global problem. Recent medications have proved to be complete treating agents because, until now no one had completely cured diabetes. Current antidiabetic drugs many undesirable side effects. So, an alternative therapy required. ...

Ficus thonningii is an African ethnomedicine plant used to treat a number of diseases. The nutritional, phytochemical, and pharmacological aspects F. in relation its therapeutic purposes are numerous. contains alkaloids, terpenoids, flavonoids, tannins, active proteins, proteins. Continue identify, isolate, quantify the ingredients, as well their medicinal purposes. Chronic toxicity, toxicology...

We have previously suggested that activation of the hypothalamic-pituitary-adrenal (HPA) axis is dependent on cyclooxygenase (COX)-2-related signaling under infectious and restraint stresses, but less dependent on it under hypoglycemic stress. In the present study, we evaluated the neuronal activity in the brain to elucidate the possible mechanisms underlying a stress-specific relevance between...

This study evaluated whether attenuation of sympathoadrenal responses to recurrent hypoglycemia is mediated by diminished noradrenergic activity in the hypothalamus. Male Sprague-Dawley rats received either once daily insulin (1.0 units/kg) injections or an equal administration of saline for 3 days. Both groups received an administration of insulin on the fourth day, during which blood glucose ...

Cassia occidentalis Linn. is extensively used in the indigenous and folklore medicine systems to treat several illnesses. However adequate characterization of hypoglycemic activity of C.occidentalis has not yet been done. The scientific evaluation of its hypoglycemic activity was, therefore, explored and also compared with the effect of a standard hypoglycemic drug, Glibenclamide. In the presen...

This study investigated the hypoglycemic, antihyperlipidemic, and renoprotective potentials of Dennettia tripetala (DT) in a rat model of diabetes. The hypoglycemic activity in crude methanol seed extract of DT (CMEDT) and methanol seed fraction of DT (MFDT) measured by glucose oxidase method was increased by 47.37% and 28.72%, respectively, after 8 hours of administration. After 10 days of tre...