A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia-c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.

An appetite simulating effect has been attributed to the hypoglycemic action of insulin and this hormone was commonly employed previously to induce a gain in weight. This appetite stimulating effect was first observed by Pitfield in 1923. His paper was followed by a series of other reports which were more or less confirmatory in nature and showed the usefulness of insulin in malnutrition. These...

A 3-year-old girl is described who became oliguric and hypoglycaemic whilst receiving an excessive dose of sulphadiazine. The mechanism of the hypoglycaemia is discussed.

M unoz, Lowry, and Smith (2012) reported the use of root cause analysis (RCA) as part of a continuous quality improvement project to reduce hypoglycemic episodes in patients following gynecological surgery. Root cause analysis is an important component of quality improvement, and nurses at all levels should understand the process and the outcomes of a RCA. Root cause analysis was used originall...

Severe hypoglycemic episodes, as defined as altered consciousness to the extent that self treatment is impossible, were sought prospectively in pregnant diabetic women. One or more episodes were found in none of 21 gestational onset, insulin-requiring women during their 28 pregnancies but were present in 19 (33%) of the 57 already insulin dependent (Type 1) women during 26 (36%) of their 72 pre...

In 2008, the Action to Control Cardiovascular Risk in Diabetes trial was halted due to an unexpected number of deaths in the intensive treatment group (aiming for hemoglobin A1c levels less than 6%). Hypoglycemic episodes were thought by some to be a contributing cause, underscoring again the challenge of maintaining tight control while avoiding dangerous excursions into hypoglycemic territory....