The objective of the study was to determine whether luteinizing hormone (LH) and prolactin (PRL) can access the brain by way of transfer from the venous blood of the cavernous sinus to the arterial blood supplying the brain and hypophysis. Studies were performed on heads of 22 mature sheep isolated during different phases of the estrous cycle and perfused with autologous blood. We were not able...

activity of estrogenic hormones (either of endogenous or exogenous origin) and the growth of mammary carcinoma in humans. Ablation of the hypophysis, the endocrine glands producing estrogens, or the administration of estrogenic hormones may induce objective regression of tumor in approximately 30 % of the patients so treated (18, 19). The basic nature of this relationship between carcinoma of t...

Immunoperoxidase histochemical investigations on pig hypophysis show that CRF immunoreactive nerve terminals are distributed around the blood vessels in the posterior lobe, particularly in its proximal part adjacent to the intermediate lobe. CRF immunoreactive nerve fibers are also seen in the intermediate lobe. The distribution of the CRF-containing nerve in the posterior lobe was found to be ...