One of the most striking examples of dysfunctional hypothalamic signaling of energy homeostasis is observed in patients with hypothalamic lesions leading to hypothalamic obesity (HO). This drastic condition is frequently seen in patients with craniopharyngioma (CP), an embryological tumor located in the hypothalamic and/or pituitary region, frequently causing not only hypopituitarism, but also ...

BACKGROUND In this study, we examined alterations in the hypothalamic reward system related to high-fat diet (HFD) preferences. We previously reported that hypothalamic 2-arachidonoylglycerol (2-AG) and glial fibrillary acid protein (GFAP) were increased after conditioning to the rewarding properties of a HFD. Here, we hypothesized that increased 2-AG influences the hypothalamic reward system. ...

GEBBER, GERARD L,, AND DAVID 's/v. SNYDER. Hypothalamic confrol of the barorecepfor reflexes. Am. J. Physiol. 2 18 ( 1) : 12+ 13 I . 1969.-The elect of hypothalamic stimulation was studied on the cardiac and vascular efferent components of the baroreceptor reflexes. Bradycardia evoked by carotid sinus nerve stimulation or norepinephrine was blocked by hypothalamic stimulation in spinal cats. Th...

In genetically obese leptin-deficient ob/ob mice, adrenalectomy reverses or attenuates the obese phenotype. Relative to lean controls, ob/ob mice also exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalamic agouti-related peptide (AGRP) mRNA and neuropeptide Y (NPY) mRNA. It has been hypothesized that this profile of hypothalamic gene expression contributes to ...

Activation or inhibition of hypothalamic GABAergic activity and immunopotentiation or immunosuppression during aging depends on the variation of the amount of dietary protein as well as the duration of its supplementation. Here we evaluate the effect of low (5%) and high (40%) protein diet on the functional state of hypothalamic GABA receptor in the aging brain in albino rats. Consumption of lo...

Ginseng effectively regulates the immune response and the hormonal changes due to stress, thus maintaining homeostasis. In addition to suppressing the occurrence of psychological diseases such as anxiety and depression, ginseng also prevents stress-associated physiological diseases. Recent findings have revealed that ginseng is involved in adjusting the hypothalamic-pituitary-adrenal axis and c...

Background: Despite several attempts, the etiopathogenesis of anorexia nervosa (AN) is still unknown. However, activation immune response in neuropsychiatric diseases, including AN, increasingly evident. We aimed to explore parameters patients with AN and identify link between presence specific autoantibodies for hypothalamic antigens inflammatory response. The relationship markers duration dis...

The development of hypothalamic lesions due to goldthioglucose are described. The initial extensive necrotic lesion occurs in close to 100 per cent of animals injected with LD(50). Within 2 weeks the necrotic material has been removed and a narrow scar results. After a lapse of several months, the scar is often difficult to visualize, especially in animals that have not developed obesity. The v...