The possibility of Pb2+, Cd2+, Ni2+ and Ba2+ ions removal from aqueous solution using light expanded clay aggregate (LECA) was investigated in this work. central composite design (CCD) response surface methodology (RSM) used to optimize the operating parameters (adsorbent granulometry, absorption time initial metal concentration) reach maximum single multi-elemental solutions. After optimizatio...

BACKGROUND The transdermal application of substances represents an elegant approach to overcome side effects related to injections or oral treatment. Due to benefits like a constant plasma level, no pain during application and a simple therapeutic regime, the optimization of formulations for transdermal drug delivery has gained interest in the last decades. Ibuprofen is a non-steroidal anti-inf...

Acute ingestion of ibuprofen commonly results in no symptoms, or minor gastrointestinal or central nervous system manifestations. While most cases of ibuprofen overdose do well, serious toxicity may occur, and is difficult to predict. A case of ibuprofen overdose is presented in which the course was complicated by metabolic acidosis, adult respiratory distress syndrome, and renal failure necess...

PURPOSE Drug release profiles were established for ibuprofen encapsulated within several types of microspheres and a range of dissolution buffer media to study the effect these variables have in controlling the rate and extent of drug release. METHODS Fatty acid microspheres containing ibuprofen were prepared by a process previously developed and refined to produce microspheres of a known siz...

Steroid and hopanoid biomarkers can be found in ancient rocks may give a glimpse of what life was present at that time. Sterols hopanoids are produced by two related enzymes, though the evolutionary history this protein family is complicated losses horizontal gene transfers, appears to widely misinterpreted. Here, I have added sequences from additional species, re-analysis phylogeny SHC OSC ind...

Prostaglandins (PG) increase in bone in response to mechanical loading and stimulate bone formation. Inhibition of cyclooxygenase (COX), the enzyme responsible for PG synthesis, by non-steroidal anti-inflammatory drugs (NSAIDs) impairs the bone formation response to loading in animals when administered before, but not after, loading. The aim was to determine whether the timing of ibuprofen use ...

recurrent aphthous stomatitis (ras) is the most common and painful oral inflammatory lesion with an unknown etiology. this study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (almgs) syrup on reducing oral aphthous ulcer pain.thirty-one patients with ras participated in this double-blind clinical trial. subjects were randomly divided ...

conclusions this study showed that administration of oral acetaminophen 30 minutes preoperatively, resulted in significantly lower pain intensity in children undergoing adenotonsillectomy in pacu and ward, compared to ibuprofen and placebo. results the average pain intensities were significantly lower in acetaminophen group based on the cheops in both pacu and ward compared to ibuprofen or plac...

Ibuprofen is used for the closure of ductus arteriosus either intravenously or enterally. Although intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, transient renal failure, oliguria, hyponatremia and thrombocytopenia are reported complications during or after ibuprofen treatment, gastrointestinal bleeding, to our knowledge, has not been reported previously. We...

The synthesis of phenylene-ethynylene rods and their use as rigid spacers is described. Alternation of a Sonogashira reaction and silyl group cleavage was used to obtain rigid spacers with even and odd numbers of phenylene units. Preliminary applications of these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer proved gr...