Dopaminergic neurotransmission in primary auditory cortex (AI) has been shown to be involved in learning and memory functions. Moreover, dopaminergic projections and D1/D5 receptor distributions display a layer-dependent organization, suggesting specific functions in the cortical circuitry. However, the circuit effects of dopaminergic neurotransmission in sensory cortex and their possible roles...

In large open pit mines prediction of Peak Particle Velocity (PPV) provides useful information for safe blasting. At Sungun Copper Mine (SCM), some unstable rock slopes facing to valuable industrial facilities are both expose to high intensity daily blasting vibrations, threatening their safty. So, controlling PPV by developing accurate predictors is essential. Hence, this study proposes improv...

This article proposes to analyze the production chains of Brazilian states regarding taxation Tax on Circulation Goods and Services (ICMS) levied Electronic Commerce (e-commerce) by final consumer, who is not taxpayer, through interstate operation. Therefore, this a comparative study rules incidence tax at national international level, as well conflicts generated federative entities, forming ty...

Inactivation of one X chromosome in female mammals (XX) compensates for the reduced dosage of X-linked gene expression in males (XY). However, the inner cell mass (ICM) of mouse preimplantation blastocysts and their in vitro counterparts, pluripotent embryonic stem cells (ESCs), initially maintain two active X chromosomes (XaXa). Random X chromosome inactivation (XCI) takes place in the ICM lin...

This paper describes the in vitro development of inner cell masses isolated immunosurgically from mouse blastocysts which had been collected on 3.5 days p.c. and then incubated for 24 h. The inner cell masses continue to grow in culture and develop through a series of stages with increasing complexity of internal organization. By day 1 all of the cultured ICMs have an outer layer of endoderm, a...

RATIONALE Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers great opportunities for cardiac disease modeling and cardiac regeneration. A major challenge of iCM generation is the low conversion rate of fibroblasts to fully reprogrammed iCMs, which could in part be attributed to unbalanced expression of reprogramming factors Gata4 (G), Mef2c (M), and Tbx5 (T) using th...

Online collaboration on lecture contents has gained much popularity, over the few decades, due to its potential to enhance the learning experience. We propose a novel idea of an online collaboration platform, called Multiscript (MS), for the students and the teacher, on classroom lectures. MS combines two online learning approaches into a single collaboration platform. One approach, called outs...

The primary motor cortex of mammals has an orderly representation of different body parts. Within the representation of each body part the organization is more complex, with groups of neurons representing movements of a muscle or a group of muscles. In rats, uncertainties continue to exist regarding organization of the primary motor cortex in the whisker and the neck region. Using intracortical...

Abstract Funding Acknowledgements Type of funding sources: None. Background The randomised SMART-MI trial demonstrated that telemonitoring with insertable cardiac monitors (ICMs) for post-acute myocardial infarction patients autonomic dysfunction and a left ventricular ejection fraction between 35-50% is highly effective in detecting serious arrhythmic events (SAE) compared to standard care (So...