OBJECTIVE To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant, primary generalized tonic-clonic (PGTC) seizures in idiopathic generalized epilepsy (IGE). METHODS In this multicenter, double-blind study (ClinicalTrials.gov identifier: NCT01393743; funded by Eisai Inc.), patients 12 years or older with PGTC seizures and IGE were randomized to placebo or peramp...

Objective To investigate social outcome and psychiatric comorbidity of patients with idiopathic/genetic generalized epilepsies (IGEs) its subtypes (epilepsy tonic-clonic seizures alone [EGTCS], juvenile absence epilepsy [JAE], myoclonic [JME]). Methods A cohort 402 adult IGE from the Danish island Funen was matched 4020 randomly selected geography-, age-, sex-matched controls via Civil Registra...

PURPOSE The transient, mainly generalized, together with brief changes in EEG baseline immediately after eye closure, is called 'eye closure sensitivity' (ECS) which was first reported by Robinson in 1930 and there have been limited number of studies investigating ECS and epilepsy syndromes. Therefore, we aimed to reveal the possible relationship between ECS and the epilepsy syndromes in our ad...

Given the grave morbidity and mortality of drug-resistant epilepsy, it is of great clinical interest to determine how often prior proven drug-resistant epilepsy is reversible without surgery and whether remission can be predicted by clinical features in children with incident drug-resistant epilepsy. We determined the likelihood of 1-, 2- and 5-year seizure remission and terminal 5-year seizure...

Juvenile myoclonic epilepsy is the most common idiopathic generalized epilepsy, characterized by frequent myoclonic jerks, generalized tonic-clonic seizures and, less commonly, absences. Neuropsychological and, less consistently, anatomical studies have indicated frontal lobe dysfunction in the disease. Given its presumed thalamo-cortical basis, we investigated thalamo-cortical structural conne...

The search for accurate clinical records of epilepsy in its relation to and modification by pregnancy and the puerperal state, with the remote effects of childbearing upon the mother's psychosis, is a difficult matter. For various reasons, especially the desire for maternity, the epileptic mother withholds imparting her true condition, and the severity, nature and frequency of her attacks. So l...

Introduction This case-control study aimed to assess two single nucleotide polymorphisms of the gene encoding the GABRG2 protein - GABRG2 (3145 G>A) and GABRG2 rs 211037 Asn196Asn (C588T) - in a cohort of pediatric patients from Romania, and evaluate their possible impact on drug-resistant forms of generalized epilepsy and recurrent febrile seizures. Material and methods One hundred and fourt...

Epilepsy is the most common neurological disorder in dogs, with an incidence ranging from 0.5% to up to 20% in particular breeds. Canine epilepsy can be etiologically defined as idiopathic or symptomatic. Epileptic seizures may be classified as focal with or without secondary generalization, or as primary generalized. Nine genes have been identified for symptomatic (storage diseases) and one fo...

Article abstract—Nonpharmacologic options for the treatment of epilepsy include epilepsy surgery, vagus nerve stimulation, and the ketogenic diet. The advantages and limitations of these treatment modalities have been extensively reviewed, but there is no general consensus on when each option should be considered. The authors propose an algorithm based on the type of epilepsy. Generally, nonpha...