Time-kill studies, even those performed with in vitro dynamic models, often do not provide definitive comparisons of different antimicrobial agents. Also, they do not allow determinations of equiefficient doses or predictions of area under the concentration-time curve (AUC)/MIC breakpoints that might be related to antimicrobial effects (AMEs). In the present study, a wide range of single doses ...

Herpes simplex virus type 1 (HSV-1) mutants defective in immediate-early (IE) gene expression do not readily enter productive replication after infection of tissue culture cells. Instead, their genomes are retained in a quiescent, nonreplicating state in which the production of viral gene products cannot be detected. To investigate the block to virus replication, we used the HSV-1 triple mutant...

PURPOSE Interesterification of palm stearin and palm kernal (PSt/PK) is widely used by the food industry to create fats with desirable functional characteristics for applications in spreads and bakery products, negating the need for trans fatty acids. Previous studies have reported reduced postprandial lipaemia, an independent risk factor for CVD, following interesterified (IE) palmitic and ste...

Open Information Extraction is a recent paradigm for machine reading from arbitrary text. In contrast to existing techniques, which have used only shallow syntactic features, we investigate the use of semantic features (semantic roles) for the task of Open IE. We compare TEXTRUNNER (Banko et al., 2007), a state of the art open extractor, with our novel extractor SRL-IE, which is based on UIUC’s...

The time-varying microstructure of sleep EEG spindles may have clinical significance in dementia studies and can be quantified with a number of techniques. In this paper, the sleep spindle is modeled as an AM-FM signal in terms of six parameters, three quantifying the instantaneous envelope (IE) and three quantifying the instantaneous frequency (IF) of the spindle model. An application of such ...

A sound's duration provides important information about the event producing it. Although many of the sounds we hear every day are 'percussive' in nature (ie resulting from two objects impacting) and therefore exhibit decaying/damped amplitude envelopes, perceptual experiments frequently use tones synthesized with 'flat' or abruptly ending envelopes. Such sounds afford an estimation strategy inv...