Intrafl agellar transport (IFT) of particles containing structural and signaling proteins is critical to building and maintaining cilia and fl agella (Kozminski et al., 1993; Rosenbaum and Witman, 2002; Scholey, 2003). Defects in IFT in humans can give rise to dysfunctional cilia and produce a variety of disease states (Pazour and Rosenbaum, 2002). Sensory cilia in Caenorhabditis elegans neuron...

As a physiochemical property, asphaltenes are known to be one the most surface active compounds in crude oil. Due to such property, their behavior is most probably influenced by fluid-fluid interactions at the contact surface (interface). Potentially and naturally, in most cases, water is in contact with crude oil and is co-produced with it as well. Considering that asphaltene molecules are pol...

Original scientific paper This research gives an overview of the Analytic Hierarchy Process (AHP) and Intuitionistic FuzzyTOPSIS (IFT) methods. This study deals with an evaluation methodology based on the AHP-IFT where the uncertainties are handled with linguistic values. First, the supplier selection problem is formulated using AHP and, then, it is used to determine the weights of the criteria...

The kinesin-2-driven anterograde transport of intraflagellar transport (IFT) trains has long been suspected to deliver cargo consisting of tubulin subunits for assembly at the axoneme tip. Important new work identifies the tubulin binding site on IFT trains that is responsible for this cargo transport.

IgG (mAb)-opsonized, inactivated Francisella tularensis LVS (iFt-mAb) enhances TLR2-dependent IL-6 production by macrophages via Fcγ receptors (FcγR). In mice, vaccination with iFt-mAb provides IgA-dependent protection against lethal challenge with Ft LVS. Because inflammasome maturation of IL-1β is thought important for antibody-mediated immunity, we considered the possibility that iFt-mAb eli...

The membrane protein composition of the primary cilium, a key sensory organelle, is dynamically regulated during cilium-generated signaling [1, 2]. During ciliogenesis, ciliary membrane proteins, along with structural and signaling proteins, are carried through the multicomponent, intensely studied ciliary diffusion barrier at the base of the organelle [3-8] by intraflagellar transport (IFT) [9...

Intraflagellar transport (IFT) machinery mediates the bidirectional movement of cargos that are required for the assembly and maintenance of cilia. However, little is known about how IFT is regulated in vivo. In this study, we show that the small guanosine triphosphatase (GTPase) adenosine diphosphate ribosylation factor-like protein 13 (ARL-13) encoded by the Caenorhabditis elegans homologue o...

Transport of proteins in the ciliary shaft is driven by microtubule-dependent motors, kinesins. Prior studies suggested that the heterotrimeric ciliary kinesin may be dispensable for certain aspects of transport in specialized cilia of vertebrate photoreceptor cells. To test this possibility further, we analyzed the mutant phenotype of the zebrafish kif3a gene, which encodes the common motor su...

Intraflagellar transport (IFT) particles are composed of polyprotein complexes IFT-A and IFT-B as well as cargo adaptors such as the BBSome. Two IFT-B subunits, IFT25 and IFT27 were found to form a heterodimer, which is essential in exporting the BBSome out of the cilium but not involved in flagellar assembly and cytokinesis in vertebrates. Controversial results were, however, recorded to show ...

the chemical surfactant flooding can mobilize the trapped oil by lowering the interfacial tension between oil and brine and in some cases altering the reservoir rock wettability. in this work, the effect of surfactants on oil/brine interfacial tension was experimentally investigated. first, the effect of surfactants concentration was surveyed. afterwards, the effect of salinity on surfactant be...