A 56-year-old male with known IgA nephropathy was admitted to our facility because of a 12-month episode of increasing proteinuria. The urinalysis was 21 for protein, negative for occult blood and with hyaline and fatty casts in the sediment. The serum creatinine was 1.07 mg/dL and creatinine clearance was 75.6 mL/min. The serum IgA was 490 mg/dL (normal range: 107–363) and serum C3 was 116 U/m...

We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. This differential lectin-binding capacity was abrogated when the experiment was ...

BACKGROUND The purpose of the current study was to investigate the pathological characteristics of chronic kidney diseases in the Tibet plateau and the plain. METHODS 77 cases from the Tibet plateau and 154 cases from the plain of renal biopsied patients with chronic kidney diseases were compared in a randomized, and parallel controlled manner. Pathological characteristics were defined accord...

Introduction Henoch Schonlien Purpura(HSP ),the most common non granulomatous ,immune complex mediated small vessel vasculitis in children involves multiple organs [1–2]. In adults and infants less than 2 years it tends to have an atypical course with higher rate of gastrointestinal and renal complications [1]. HSP nephritis is reported to occur in 20-80% of patients and characterized by mesang...

IgA Nephropathy (IgAN) is a very common glomerulonephritis worldwide, especially in Asia, which is an important cause of progressive kidney disease with 25–30% of patients developing end-stage renal disease within 20 years of diagnosis. IgA nephropathy can be in different age bracket onset, but mainly in adults. The treatment of primary IgA nephropathy we mentioned in this article is only for a...

IgA nephropathy is one of the most common causes of glomerulonephritis in the world and is characterized histologically by the deposition of polymeric forms of IgA within the mesangium and in some cases along the glomerular capillary wall.(1) Proliferative and crescenteric forms of IgA are associated with nephrotic range proteinuria, accelerated hypertension, and a more rapid decline toward end...

BACKGROUND The pathogenesis of ANCA-associated pauci-immune glomerulonephritis has not been fully elucidated. Several studies had suggested that complement deposition could be detected in renal histopathology. The current study investigated the clinical and pathological significance of complement deposition in renal histopathology of patients with ANCA-associated pauci-immune glomerulonephritis...

BACKGROUND While some studies have reported that IgA nephropathy has a relatively benign clinical course in children, others have shown that renal outcomes of paediatric patients with IgA nephropathy followed into adulthood are similar to those of patients diagnosed as adults. Some of this variability may be related to differences in histologic severity of cohorts of patients diagnosed as child...

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis in the developed world and it is an important cause of end stage kidney failure. Epidemiologic studies have shown that IgAN is nearly universally distributed around the world but the frequency with which it is diagnosed varies, mostly according to local policies regarding the indications for renal biopsy. Prevalence ap...