نتایج جستجو برای: igfbp1
تعداد نتایج: 229 فیلتر نتایج به سال:
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with substantial morbidity and mortality. The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression. METHODS AND FINDINGS We analyzed the co...
Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-...
Previous work has shown that the evolution of both insulin-like growth factor 1 (IGF1) and insulin shows an episode of accelerated change on the branch leading to New World Monkeys (NWM). Here the possibility that this is accompanied by a corresponding episode of accelerated evolution of IGF1 receptor (IGF1R), insulin receptor (IR) and/or IGF binding proteins (IGFBPs) was investigated. Analysis...
OBJECTIVE The objective of this study was to determine maternal hormonal and metabolic factors associated with insulin sensitivity in human pregnancy. RESEARCH DESIGN AND METHODS This was a prospective observational cross-sectional study of 180 normal pregnant women, using samples collected at the time of a blinded oral glucose tolerance test (OGTT) between 24 and 32 weeks' gestation as an an...
Hyperemesis gravidarum leads to alterations in maternal (and possibly fetal) nutrition throughout pregnancy, but there are no data on the long-term metabolic health outcomes in the offspring. We hypothesized that hyperemesis gravidarum could lead to fetal nutritional compromise or physiological stress, which may programme later metabolism and body composition. Two groups of healthy pre-pubertal...
BACKGROUND The decidua has been implicated in the "terminal pathway" of human term parturition, which is characterized by the activation of pro-inflammatory pathways in gestational tissues. However, the transcriptomic changes in the decidua leading to terminal pathway activation have not been systematically explored. This study aimed to compare the decidual expression of developmental signaling...
We recently showed from a Swedish cohort that nearly half of boys born post-term (≥42 weeks gestation) were overweight or obese at 16 years of age. We hypothesized that post-term children would display features of insulin resistance and the metabolic syndrome even in their pre-pubertal years. 90 healthy pre-pubertal children aged 4–11 years, with birth weight appropriate-for-gestational-age wer...
AIMS Reduced levels of free and total insulin-like growth factor 1 (IGF-I) have been observed in type-1 diabetes (T1D) patients. The bioavailability of IGF-I from the circulation to the target cells is controlled by multifunctional IGF-binding proteins (IGFBPs). The aim of this study was to profile serum IGFBPs in T1D and its complications. DESIGN We measured the IGFBP levels in 3662 patient ...
BACKGROUND Decidualization (differentiation) of the endometrial stromal cells during the secretory phase of the menstrual cycle is essential for successful implantation. Transforming Growth Factor β1 (TGFβ1) canonically propagates its actions via SMAD signalling. A role for TGFβ1 in decidualization remains to be established and published data concerning effects of TGFβ1 on markers of endometria...
By N-terminal sequence comparison it was shown that the placental protein 12 (PP12)(1) is homologous to the IGF I (insulin-like growth factor) and somatomedin binding protein (2-4). Starting with an antibody raised against PP12 we have screened cDNA libraries from human placenta. Two cDNA clones were identified with an open reading frame encoding a hydrophobic leader peptide consisting of 25 aa...
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