IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disease characterized by tumefactive lesions in various organ systems, including the lungs. Clinical and radiological manifestations of IgG4-RD are relatively non-specific, and we report a case highlighting the importance of histopathological confirmation in cases of suspected IgG4-related lung disease. A 44-year-old male with signi...

Despite its well-known association with IgE-mediated allergy, IgG4 antibodies still have several poorly understood characteristics. IgG4 is a very dynamic antibody: the antibody is involved in a continuous process of half-molecules (i.e. a heavy and attached light-chain) exchange. This process, also referred to as 'Fab-arm exchange', results usually in asymmetric antibodies with two different a...

BACKGROUND IgG4-TIN is the most common pattern of renal involvement in IgG4-related disease. There are several proposed diagnostic criteria of IgG4-TIN recently. Two of them proposed by the Mayo Clinic and JSN are predominant. However, histopathological criteria of the number of IgG4+ plasma cells and several histological features are still under discussion due to low amount of tissue in renal ...

Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of + plasma cells in the affected organs. The present study aimed to characterize levels coinhibitory checkpoint molecule, T cell immunoglobulin mucin-containing-molecule-3 (TIM-3), its ligand, galectin-9 (Gal-9), among IgG4-related patients with IgG4-RD variou...

Background: IgG4-related ophthalmic disease (IgG4-ROD) is one of the phenotypes (IgG4-RD), and its lesions are mainly located in ocular. Currently, there few studies on IgG4-ROD no study has compared phenotypic differences between non (nIgG4-ROD). Thus, it difficult to establish optimal treatment strategy for IgG4-ROD. Objectives: The aim this was identify disparities two groups clarify risk fa...

Introduction. IgG4-related disease (IgG4-RD) is currently known as a unique progressive immune-mediated creating tumor-like fibrotic masses in different organs of the human body. Case presentation. We report 23-year-old woman who presented with acute abdominal pain, icterus, and fever. A biliary stricture aroused suspicion cholangiocarcinoma. In addition, some colon were observed, which suspect...

IgG4 is the least abundant IgG subclass in human serum, representing less than 5% of all IgG. Increases in IgG4 occur following chronic exposure to antigen and are generally associated with states of immune tolerance. In line with this, IgG4 is regarded as an anti-inflammatory antibody with a limited ability to elicit effective immune responses. Furthermore, IgG4 attenuates allergic responses b...

INTRODUCTION B cell-activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) play a crucial role in B cell development, survival, and antibody production. Here we analyzed the serum levels of BAFF and APRIL and their respective clinical associations in patients with an immunoglobulin (Ig) G4-related disease (IgG4-RD). METHODS We measured serum l...

In order to investigate the association between IgG4 autoantibody and complement abnormalities in systemic lupus erythematosus (SLE), 72 newly diagnosed SLE patients, 67 rheumatoid arthritis (RA) patients, and 41 healthy normals were employed. Serum levels of antinuclear IgG4 and IgG4-specific IgM-rheumatoid factor (RF) were measured, and the correlations between serum levels of antinuclear IgG...

BACKGROUND The diagnosis of Immunoglobulin G4 (IgG4)-related disease (IgG4-RD), in general, depends on serum IgG4 concentrations and histopathological findings; therefore, diagnosis of IgG4-RD in cardiovascular organs/tissues is often difficult owing to the risk of tissue sampling. METHODS Prevalence of IgG4-positive lymphoplasmacytic infiltration in 103 consecutive cardiovascular surgical sa...