T lymphocytes express a plethora of distinct ion channels that participate in the control of calcium homeostasis and signal transduction. Potassium channels play a critical role in the modulation of T cell calcium signaling, and the significance of the voltage-dependent K channel, Kv1.3, is well established. The recent cloning of the Ca(2+)-activated, intermediate-conductance K(+) channel (IK c...

Gives a brief overview of indigenous knowledge in Sri Lanka and examines the level of preservation and the provision of access to it through the libraries in Sri Lanka. Although the country inherits a vast amount of indigenous knowledge, the library system or any other institute in the country has not yet taken concerted effort to preserve and provide access to this knowledge. Indigenous Knowle...

In the liver, adenosine triphosphate (ATP) is an extracellular signaling molecule that is released into bile and stimulates a biliary epithelial cell secretory response via engagement of apical P2 receptors. The molecular identities of the ion channels involved in ATP-mediated secretory responses have not been fully identified. Intermediate-conductance Ca(2+)-activated K(+) channels (IK) have b...

In this paper, we study the existence of solution of the four-point boundary value problem for second-order differential equations with impulses by using Leray-Schauder theory: ⎧⎨ ⎩ x′′(t) = f(t, x(t), x′(t)), t ∈ [0, 1], t = tk, k = 1, 2,··· ,m Δx(tk) = Ik(x(tk)), k = 1, 2,··· ,m Δx′(tk) = Ik(x(tk), x ′(tk)), k = 1, 2,··· ,m x(0) = αx(ξ), x′(1) = βx′(η), (E) where 0 < ξ ≤ η < 1, α ≥ 0, β ≥ 0 a...

We present a duality for the intuitionistic modal logic IK introduced by Fischer Servi in [8, 9]. Unlike other dualities for IK reported in the literature (see for example [13]), the dual structures of the duality presented here are ordered topological spaces endowed with just one extra relation, which is used to define the set-theoretic representation of both 2 and 3. Also, this duality natura...

Some schools do not have local formal work environments enabling learners to interact with members in community of practice. This is noticeable in schools in developing countries, including the north eastern Zambezi Region of Namibia, where the study took place. To close the gap in which trainee science and mathematics teachers who were the participants failed to contextualize teaching and lear...

The Interdisciplinary College (IK) is an annual, intense one-week spring school which offers a dense state-of-the-art course program in neurobiology, neural computation, cognitive science/psychology, artificial intelligence, robotics and philosophy. It is aimed at students, postgraduates and researchers from academia and industry. By combining humanities, science and technology, the IK endeavou...

This paper presents a novel whole-body analytical inverse kinematics (IK) method integrating collision avoidance and customizable body control for animating reaching tasks in real-time. Whole-body control is achieved with the interpolation of pre-designed key body postures, which are organized as a function of the direction to the goal to be reached. Arm postures are computed by the analytical ...