OBJECTIVE As a candidate gene association study, we investigated the genetic association of SNPs in IL-28B genes with different outcomes of HBV infection, including LC and HCC occurrence. METHODS Chinese Han subjects were categorized into two groups: 406 LC caused by CHB and 406 HCC caused by CHB. Genomic DNA was isolated from whole blood samples, SNPs were detected using high resolution melt...

aim : the purpose of this study was to compare the distribution of interleukin (il)-28b genotypes between iranian healthy individuals and patients with chronic hepatitis c based on the genotype. background : polymorphisms in the region of il-28b gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (svr) in hepatitis c infection. patients an...

At the beginning of the third millennium, Hepatitis C virus (HCV) infection continues to be a major health hazard, with 170 million chronically infected people worldwide (1). Recent research has found that the prevalence of HCV infection in Iran is 1% and 0.1% in males and females, respectively (2). Although a combination of pegylated interferon (PEG-IFN) and ribavirin (RBV) has been establishe...

BACKGROUND Hepatitis C virus (HCV) is associated with a higher prevalence of steatosis compared to the general population. AIM Our aim was to assess the impact of PNPLA3 rs738409 G-allele on steatosis in HCV patients. MATERIAL AND METHODS We included 474 HCV patients treated with peginterferon plus ribavirin. PNPLA3 rs738409 was genotyped and patients were classified according to alleles an...

UNLABELLED Although 20%-40% of persons with acute hepatitis C virus (HCV) infection demonstrate spontaneous clearance, the time course and factors associated with clearance remain poorly understood. We investigated the time to spontaneous clearance and predictors among participants with acute HCV using Cox proportional hazards analyses. Data for this analysis were drawn from an international co...

IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection Vito Di Marco, Fabrizio Bronte, Vincenza Calvaruso, Marcello Capra, Zelia Borsellino, Aurelio Maggio, Maria Concetta Renda, Lorella Pitrolo, Maria Carmela Lo Pinto, Michele Rizzo, Flavia Fiorenza, Calogera Gerardi, Stefania Grimaudo, Anto...

Concurrent infection with hepatitis C virus (HCV) and hepatitis B virus (HBV) was not uncommon in China. To date, information on predictors of response to treatment of dually-infected HCV/HBV is limited. The aim of this study was to evaluated whether determination of the interleukin 28B (IL-28B) polymorphism statuses sufficient to predict treatment response of interferon (IFN)-based therapy in ...

INTRODUCTION Recent studies have demonstrated the role of the interleukin 28B (IL28B) polymorphisms in predicting treatment induced and spontaneous clearance from Hepatitis C virus (HCV) infection, suggesting the possibility of tailored therapy in HCV infected patients. Genome-wide association studies have shown that single nucleotide polymorphisms (SNPs) near IL 28B gene on chromosome 19 are s...

BACKGROUND IL28B single nucleotide polymorphisms (SNPs) play important roles in the management of hepatitis C virus (HCV) infections and are strongly associated with spontaneous and treatment-induced HCV clearance. OBJECTIVES In the present study, the association between IL28B variants and the progression of HCV infection in Egyptian patients infected with type 4a virus will be examined. PA...

BACKGROUND Egypt has one of the highest prevalences of hepatitis C virus (HCV) infection worldwide. Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population. MATERIALS AND METHODS The IL28B rs12979860 single nucleotide polymorphism (SNP) was therefore examined in 256 HCV-infected Egyptian ...