Two methodologies for fitting radiotracer models on a pixel-wise basis to PET data are considered. The first method does parameter optimization for each pixel considered as a separate region of interest. The second method also does pixel-wise analysis but incorporates an additive mixture representation to account for heterogeneity effects induced by instrumental and biological blurring. Several...

For deep tissue photoacoustic imaging, piezoelectric ultrasound detectors with large element sizes (>1mm) and relatively low centre frequencies (<5MHz) are generally used, as they can provide the required high sensitivity to achieve imaging depths of several centimetres. However, these detectors are generally not optimised in terms of element size and bandwidth. To identify these parameters in ...

Images of astronomical objects acquired by ground-based telescopes are blurred by atmospheric turbulence. These blurring effects can be partially overcome by post-detection processing such as speckle imaging (SI). We have developed a parallel implementation of SI to dramatically reduce the time required to reduce imaging data, allowing us to implement a near realtime (NRT) SI image feedback cap...

State-of-the-art radioactive drug development has become a helpful tool in new functional imaging technologies in neurosciences. Drug development programs are evaluated in terms of effective biodistribution, costs and time. This article details the existing drug development parameters for neuroimaging and highlights some examples, as in Parkinson's disease, alcoholic neuritis and psychotic dise...

BACKGROUND & OBJECTIVES Non-invasive and non-ionizing medical imaging techniques are safe as these can be repeatedly used on as individual and are applicable across all age groups. Breast thermography is a non-invasive and non-ionizing medical imaging that can be potentially used in breast cancer detection and diagnosis. In this study, we used breast thermography to estimate the tumour contour ...

 ABSTRACTBackground: Delivering the radiation dose to the target volume and minimizing the dose to normal tissues are the main objectives in radiotherapy. The aim of our study is to enhance the contrast of the portal image to increase the accuracy of delineation of the organs in the irradiation field.   Methods: The software was written based on local enhancement of the pixel values in image ma...

Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) of the breast is a routinely used imaging method which is highly sensitive for detecting breast malignancy. Specificity, though, remains suboptimal. Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI), an alternative dynamic contrast imaging technique, evaluates perfusion-related parameters unique from DCE MRI. Prev...

We present an iterative approach to solve separable nonlinear least squares problems arising in the estimation of wavelength-dependent point spread function (PSF) parameters for hyperspectral imaging. A variable projection Gauss-Newton method is used to solve the nonlinear least squares problem. An analysis shows that the Jacobian can be potentially very ill-conditioned. To deal with this ill-c...

J. Lätt, S. Brockstedt, R. Wirestam, E. Larsson, F. Ståhlberg Department of Radiation Physics, Lund University, Lund, Sweden, Department of Radiology, Lund University Hospital, Lund, Sweden Synopsis Structural information of the confining geometry of water molecules can be revealed by q-space analysis of highly diffusion encoded images. An advantage of q-space analysis based on high b-values is...