Dandruff is a common scalp condition. The immune-microenvironment of dandruff skin remains poorly characterised and the hair follicle’s physiological immune privilege (HF IP) status in completely unknown. We hypothesised that latter might be important context dandruff-associated inflammation as HF IP expected to impact on overall immunophysiology. analysed expression biomarkers (CD200, MHC clas...

PURPOSE Immune privilege of the eye protects the nonregenerative ocular tissues from innate and adaptive immune-mediated inflammation. In the case of intraocular tumors, immune privilege can be arrested to allow for immune-mediated rejection. Activation of innate immune cells can contribute to necrosis of the intraocular tumor and bystander ocular tissue. Identifying the cellular components of ...

The brain has a tightly regulated environment that protects neurons and limits inflammation, designated "immune privilege." However, there is not an absolute lack of an immune response. We tested the ability of the brain to initiate an innate immune response to a virus, which was directly injected into the brain parenchyma, and to determine whether this response could limit viral spread. We inj...

Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both of these functions are upheld by the immune system, though the latter is often overlooked in the context of the CNS. The mere presence of immune cells in the CNS was long considered a hallmark of pathology, but this view has been recently challenged by studies demonstrating that immunological signaling ca...

Eye complications are common in vasculitis, especially in Wegener’s granulomatosis (WG), where up to 50% of all cases have ophthalmic involvement. Eye involvement in the Churg-Strauss syndrome (CSS) has been reported but is rare. Corneal autoantigens have been documented in patients with WG and CSS; in particular, circulating autoantibodies to corneal specific keratin 3 (K3) are present in 60% ...

Background: Alopecia areata is one of the most common autoimmune diseases. The pathobiology of this chronic, relapsing hair-loss disorder is not fully understood, and the available therapies are disappointing. Objective: Currently considered a T-cell-mediated autoimmune disease, in which the gradual loss of protection provided by immune privilege of the normal hair follicle plays an important r...