AIMS Antibodies against CD56 are primarily used in flow cytometric studies to detect natural killer cells. However, they may be useful in the identification of neuroendocrine malignancies, especially if the cells do not express CD45, indicating a non-leucocyte origin. METHODS A retrospective review was conducted on all solid tissue flow cytometric studies performed between January 1997 and Se...

Among oral lesions, we encounter a series of malignant epithelial lesions that go through clinical and histopathologic processes in order to be diagnosed. Identifying these processes along with the etiology knowledge of these lesions is very important in prevention and early treatments. Dysplasia is the step preceding the formation of squamous cell carcinoma in lesions which have the potential ...

The clinical and histopathological distinction between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is essential, but frequently difficult to make. The utility of CK17 and Ki-67 expression in distinguishing between KA and SCC was investigated. Immunohistochemical staining patterns for CK17 and Ki-67 were evaluated in 24 KA and 27 SCC cases. The pattern of staining was evaluated as cen...

The pathologic classification of rhabdomyosarcoma (RMS) into embryonal or alveolar subtype is an important prognostic factor guiding the therapeutic protocol chosen for an individual patient. Unfortunately, this classification is not always straightforward, and the diagnostic criteria are controversial in a subset of cases. Ancillary studies are used to aid in the classification, but their pote...

Crohn's disease is a chronic inflammatory bowel disease, whose aetiology and pathogenesis are still unknown. The occurrence of epithelioid granulomas is one characteristic feature of the disease since these lesions are found in the bowel wall in 50-87% of colectomy specimens. Although granulomas are not pathognomonic, their identification is considered a relevant element for diagnosis. Cathepsi...

subcutaneous panniculitis-like t-cell lymphoma (sptcl) is an infrequent cytotoxic t-cell lymphoma of the skin with a unique immunophenotypic profile. here we describe this lymphoma in a 30-year-old iranian woman. she presented with periorbital edema, mandibular swelling with edematous areas on her face and two small lymph nodes (6-7mm) in the cervical area. histopathological findings revealed l...

For classification purposes, proper identification of infrequent and unique salivary gland tumors requires the gradual accumulation of a sufficient number of cases. Lymphadenoma (i.e., an adenomatous, generally parotid-based lesion with an exaggerated lymphocytic infiltrate, but a lack of sebaceous differentiation) has approximately 9 reported cases. This report adds 2 additional cases occurrin...

Immunohistochemical Comparison of p53 Expression, Intensity and Distribution in Different Papillary Urothelial Cancers