Kaposi sarcoma (KS) is a low-grade mesenchymal angioproliferative disorder that requires infection with human herpes virus 8 (HHV-8) for it to develop. It commonly seen in HIV-positive patients and rarely immunosuppressed HIV-negative patients. Rituximab monoclonal anti-CD20 chimeric murine/human immunoglobulin G antibody used treat B cell lymphoproliferative diseases as well variety of autoimm...

Mucormycosis is an uncommon fungal infection caused by Mucorales. It frequently occurs in patients with neutropenia, diabetes, malignancy and on corticoid therapy. However, it is rare in patients with AIDS. Clinical disease can be manifested in several forms. The case reported illustrates the rare occurrence of chromoblastomycosis and mucormycosis in an immunosuppressed patient with multibacill...

Pseudomembranous necrotising bronchial aspergillosis is a variety of invasive aspergillosis found in immunosuppressed patients. A case is presented of a 66 year old woman whose only underlying disease was chronic airways limitation. The pathological findings and clinical implications are discussed.

We present the case of a patient with a locally advanced hypopharyngeal carcinoma who developed a severe cytomegalovirus (CMV) colitis after his first chemotherapy course with 5-fluorouracil (5-FU), docetaxel and cisplatin. The most probable cause of his CMV colitis is the impaired immunity during a phase of neutropenia after the chemotherapy. Although there was amelioration of the colitis and ...

AIM To investigate the effect of inducible nitric oxide synthases (iNOS) on inflammatory reactions during endotoxin-induced uveitis (EIU) in mice by studying leukocyte-endothelial cell interactions. METHODS EIU was produced in immunosuppressed iNOS(-/-) mice and C57BL/6 (normal) mice by footpad injection of lipopolysaccharide. Leukocytes were labelled with acridine orange. Leukocyte rolling i...

This study defined the in situ transcriptomics of cellular subsets epidermis and dermis lesional perilesional skin squamous cell carcinoma (SCCIS), a precursor to cutaneous (cSCC), identify novel prognostic therapeutic biomarkers. Solid organ transplant patients are 65-250 times more likely develop cSCC have an 8-fold increased risk developing metastatic disease compared non-immunosuppresed pat...

OBJECTIVE To describe a treatment and follow-up protocol for HIV patients with anal dysplasia or warts, which are at risk of malignant change. DESIGN An ongoing study of highly selected patients referred to a single surgeon. SETTING The Colorectal and HIV/AIDS Clinics, University of Ottawa, General Campus. PATIENTS Ninteen young men who presented with suspicious anal lesions and were refe...

The Green Book recommended in 2009 that immunosuppressed patients should be receiving the yearly seasonal flu vaccine, the pandemic swine influenza A H1N1/09 vaccine and should have had the single pneumococcal vaccination. A retrospective audit in 2010 involving 60 immunosuppressed patients revealed that 83.3% of participants were aware of their entitlement to the vaccines. The majority were in...

Introduction: Kaposi sarcoma is a vascular neoplasm composed of endothelium-lined vascular spaces and spindle-shaped cells. It often manifests with multiple vascular nodules on the skin and other organs. Kaposi sarcoma is rare in HIV negative patients and it is associated with HHV-8 infection. There are four types: classic, endemic, iatrogenic and HIV-associated. Patients with HIV/AIDS are also...