The transcription factor (TFs) BES1, which mediates brassinosteroid (BR) signaling, regulates plant growth and development. However, BES1 genes have not yet been reported in Tartary buckwheat. Here, ten FtBES1 were identified the buckwheat genome, they named FtBES1-1 to FtBES1-10. These divided into four groups according classification Arabidopsis thaliana. Multiple sequence alignment indicated...

nowadays, environment-sensitive smart drug delivery systems have found diverse applications in pharmaceutical science and technology. these systems can respond to the environment stimuli such as temperature, pressure, ph, light, electrical and magnetical fields and etc. they can release the proper amount of drug in human body. among these systems, special attention and much research works have ...

Recognizing genes with distinctive expression levels can help in prevention, diagnosis and treatment of the diseases at the genomic level. In this paper, fast Global k-means (fast GKM) is developed for clustering the gene expression datasets. Fast GKM is a significant improvement of the k-means clustering method. It is an incremental clustering method which starts with one cluster. Iteratively ...

Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes, but have not been previously reported as beneficial for cluster headache. We present a patient with cluster headache who was refractory to multiple acute and preventive medications but successfully aborted his attacks with recreational marijuana use; subseque...

Background: Immune response is key in defense against basal cell carcinoma (BCC). We aim to better define the immune tumor microenvironment this cancer. Methods: CD8+ infiltrating lymphocytes (TILs) obtained from fresh BCC specimens nodular subtype (“nBCC”, n=6) versus infiltrative (“iBCC”, were subject single-cell RNA profiling. Data analyzed using iCellR. Results: TILs clustered based on gene...

UNLABELLED Burkholderia thailandensis has three acyl-homoserine lactone (AHL) LuxR-LuxI quorum-sensing circuits and two orphan LuxR homologs. Orphans are LuxR-type transcription factors that do not have cognate LuxI-type AHL synthases. One of the orphans, MalR, is genetically linked to the mal gene cluster, which encodes enzymes required for production of the cytotoxic polyketide malleilactone....

Iron-sulfur (Fe-S) clusters are required for critical biochemical pathways, including respiration, photosynthesis, and nitrogen fixation. Assembly of these iron cofactors is a carefully controlled process in cells to avoid toxicity from free iron and sulfide. Multiple Fe-S cluster assembly pathways are present in bacteria to carry out basal cluster assembly, stress-responsive cluster assembly, ...