A graft-versus-host reaction was induced in (BALB/c x C5 7BL/6)F(1) mice by intravenous injection of BALB/c spleen cells. Six days later, the mice received subcutaneous grafts of a chemically induced BALB/c sarcoma. The growth of the tumor grafts was accelerated.

BACKGROUND Currently there is no vaccine available in use against any form of leishmaniases worldwide. OBJECTIVE To assess potential of a live-attenuated Leishmania major promastigates, for protection against a challenge infection with L. major in BALB/c mice. DESIGN A laboratory based study. SETTING Study was carried out at Centre for Biotechnology Research and Development, Kenya Medical...

Seven Aspergillus calidoustus isolates from 486 Aspergillus spp. isolates (1.4% overall prevalence) from outdoor/indoor air samples and one isolate from the bronchoalveolar lavage fluid of a patient with pneumonia were obtained. These 8 isolates exhibited reduced susceptibility to triazoles. Preliminary pathogenicity data from BALB/c mice suggest that A. calidoustus can persist in tissues for l...

We have examined the level of cyclin E, a G1 cyclin, and p27kip, a cyclin-dependent kinase inhibitor, in BALB/c 3T3 cells. Cell populations stimulated to undergo cell cycle traverse displayed little change in the level of cyclin E, while p27kip was found to be reduced 50-80% in proliferating cells. Analysis of mitotic cells, however, revealed that cyclin E is virtually absent and begins to reac...

Increased production of IL-10 has been frequently associated with augmented susceptibility to infection. However, the correlation between IL-10 activity and susceptibility to mycobacterial infection is still uncertain. Although studies using transgenic mice overexpressing IL-10 consistently showed an increased susceptibility to mycobacterial infection, experimental approaches in which IL-10 act...

In vitro studies have shown that both macrophage activation and destruction of parasitized macrophages lead to leishmania destruction. The relative role played by such mechanisms in vivo have not been properly evaluated. We took advantage of the model of intravenous immunization with solubilized leishmanial antigen which renders partially resistant the otherwise highly susceptible BALB/c mice t...

Several confounding factors may influence the outcome of an experiment and the extent of inter-individual variation. The aim of this study was to investigate if cage enrichment induces an effect on experimental mean values and on inter-individual variation in the light/dark paradigm using diazepam as the anxiolytic drug. The behaviour of 216 naive adult male mice of two different strains (BALB/...

Mouse models of orthopoxvirus disease provide great promise for probing basic questions regarding host responses to this group of pathogens, which includes the causative agents of monkeypox and smallpox. However, some essential tools for their study that are taken for granted with other mouse models are not available for these viruses. Here we map and characterize the initial CD8+ T-cell determ...

To further investigate the chemical mechanisms involved in the accumulation of drugs or other compounds in hair, we characterized histologically the deposition of radiolabeled serum constituents in the hair of BALB/c (albino) and C57 (pigmented) mice. The extent and location of the incorporation of a normal serum cation ((45)Ca(2+)), a serum anion ((36)Cl(-)), a neutral constituent ([(14)C]urea...

Kudoa septempunctata (Myxozoa: Multivalvulida) infects the muscles of olive flounder (Paralichthys olivaceus, Paralichthyidae) in the form of spores. To investigate the effect of K. septempunctata spores in mammals, adult BALB/c mice were fed with spores of K. septempunctata genotype ST3 (1.35 × 10(5) to 1.35 × 10(8) spores/mouse). After ingestion of spores, the mice remained clinically normal ...