“When you are high, it is tremendous. Shyness goes, the right words and gestures are suddenly there, the power to seduce and captivate others a felt certainty. Feelings of ease, intensity, power, well-being, financial omnipotence and euphoria now pervade one’s marrow. But somehow, this changes. The fast ideas are far too fast and there are far too many, overwhelming confusion replaced by fear a...

Maxillectomy often leads to oralnasal or excessive oral-pharyngeal communication. The remaining teeth may need further preparation for various reasons, including crown or fixed dental prosthesis restoration. High-volume water is used in conjunction with highspeed tooth preparation to avoid the excessive heat generation that could endanger the health of the pulp. The water aerosol generated by t...

The photooxidation of thebaine (3) with a sun lamp affords two main products: hydrodibenzofuran 10 (major) and benzofuran 11 (minor). The latter compound becomes predominant if a Hg lamp is used instead of a sun lamp. The formation of 10 proceeds via an endoperoxide intermediate that undergoes oxidation at the nitrogen atom. Protection of the nitrogen either by protonation or quaternization pre...

Metallic materials are widely employed in engineering constructions, and one of the most common failure mechanisms metals is fatigue failure. Even though metal has been studied for almost 160 years, many problems remain unsolved. Fatigue occurs when metallic material subjected to varying loads, resulting due damage accumulation. The process consists a buildup that leads crack initiation, follow...

Background & aim: Early breastfeeding initiation (EBFI) defined as giving breast milk within the first hours following birth, which is recommended as a simple strategy for the enhancement of neonatal health and survival. This descriptive qualitative study was conducted to explore the practices, perceptions and beliefs of renowned traditional birth attendants (TBA) regarding EBFI in Chipinge rur...

OBJECTIVE In clinical trials of RA patients on traditional DMARDs, the addition of TNF-alpha antagonists increased infections compared with addition of placebo. Our objective was to compare serious infections following initiation of different RA regimens. Prior comparative studies of DMARD initiation have yielded conflicting results. METHODS We estimated hospitalization rates for infections f...

BACKGROUND Mortality and morbidity from HIV have dramatically decreased in both high- and low-income countries. However, some patients may not benefit from combination antiretroviral therapy (cART) because of inadequate access to HIV care, including attrition after care initiation. METHODOLOGY/PRINCIPAL FINDINGS The study population included all HIV-infected patients receiving cART through th...

We report a temporal order of tooth addition in the Australian lungfish where timing of tooth induction is sequential in the same pattern as osteichthyans along the lower jaw. The order of tooth initiation in Neoceratodus starts from the midline tooth, together with left and right ones at jaw position 2, followed by 3 and then 1. This is the pattern order for dentary teeth of several teleosts a...

BACKGROUND This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery. METHODS This retrospective observational study included a hospital-based cohort of 200 patients diagnosed with severe RA who received treatment with anti-TNF therapy between 2003 and 2014....