Three novel new compounds derived from antiparasitic precursors have been synthesized and tested for their antiamoebic and antigiardial activities. The condensation of 2-(2-methyl-5-1H-nitroimidazolyl)ethylamine (6) with 5-nitro-2-furylacrylic acid (7) gave 3-(5-nitrofuran-2-yl)-N-[2-(5-nitroimidazol-1-yl)ethyl]acrylamide (8). Condensation of 7 with 7-chloro-4-(piperazin-1-yl)quinoline (9) affo...

In the title compound, C(16)H(12)BrN(3)O(2)S, the dihedral angle between the planes of the almost planar (r.m.s. deviation = 0.0263 Å) quinoline group and the bromo-phenyl group is 87.4 (1)°. The torsion angle of the central S-N-N-C bridge is 144.8 (2)°. The amino group has an intra-molecular contact to the quinoline N atom. The structure is stabilized by one N-H⋯O and two C-H⋯O inter-molecular...

In the title compound, C(15)H(12)ClN(3)O, the quinoline ring system is essentially planar, with a maximum deviation of 0.017 (1) Å. The crystal packing is stabilized by π-π stacking inter-actions between the quinoline rings of adjacent mol-ecule, with a centroid-centroid distance of 3.5913 (8) Å. A weak C-H⋯π contact is also observed between mol-ecules.

Acenes such as pentacene have been widely studied over the last decade because of their highly promising potential as organic semiconductors, and have found use in devices such as photovoltaics and field-effect transistors. Nonetheless, the locked s-cis diene units within acenes are an Achilles' heal, in that many acenes readily dimerize and react with oxygen. As a possible alternative, we have...

In the title spiro-indeno-quinoxaline compound, C(22)H(14)N(6)O·C(2)H(6)O, the five-membered ring of the indene unit and the pyran ring are perpendicular [89.11 (3)°]. In the crystal, N-H⋯N hydrogen bonds connect the spiro-indeno-quinoxaline mol-ecules, and the ethanol solvent mol-ecules complete the hydrogen-bond network via O-H⋯N and N-H⋯O inter-actions.

In the title compound, C(20)H(20)N(2)O, the dihedral angle between the quinoline ring system and the phenyl ring is 49.40 (5)°. In the crystal structure, zigzag layers of mol-ecules, in which the quinoline units are parallel to the (10) plane, are arranged perpendicular to the b axis. Inter-molecular N-H⋯O hydrogen bonds connect the mol-ecules into chains along [010], reinforcing the cohesion b...

The title compound, Artonol B, C(24)H(20)O(7), isolated from the stem bark of Artocarpus kemando, consists of four six-membered rings and one five-membered ring. The tricyclic xanthone ring system is almost planar [maximum deviation 0.115 (5) Å], whereas the pyran-oid ring is in a distorted boat conformation·The furan ring is almost coplanar with the fused aromatic ring, making a dihedral angle...

Intra and intermolecular interactions found in the developed crystals of synthesized py-ron-2,4-dione derivatives play crucial rules molecular conformations crystal stabili-ties, respectively. In this regard, Hirshfeld calculations were used to quantitatively analyze different structures some functionalized py-ran-2,4-dione derivatives. The X-ray structure pyran-2,4-dione derivative namely (3E,...