Upon perception of certain stimuli, plants can develop a conditioned state enhanced defensive capacity against upcoming pathogens and pests, resulting in phenotype called ‘induced resistance’ (IR). Scientific communication the IR research domain is flawed with inconsistent use various conceptualizations terms. Researchers working on non-model organisms and/or less-studied plant tissues – which ...

Extensive research into mechanisms of cytotoxic drug resistance and subsequent clinical trials of drug resistance modifiers have produced few encouraging results. In this report, we analyze 4,400+ ex vivo Differential Staining Cytotoxicity (DiSC) assay drug response results from patients with chronic lymphocytic leukemia (CLL) to investigate the development of drug resistance during treatment. ...

induction of systemic resistance to cucumber against marginal leaf blight disease caused by pseudomonas marginalis using silicon application (as 1 &2 mm of sodium silicate) was studied under greenhouse conditions. results indicated that application of 2 mm of sodium silicate remarkably increased resistance in cucumber against the pathogen. according to the results, disease severity in plants tr...

Background and Objectives: Muscular atrophy is one of the indicators of uncontrolled diabetes. The aim of the current study was to investigate effects of eight weeks of resistance training (RT) on myostatin gene expression in soleus muscles and insulin resistance in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In general, 14 Wistar male rats weighing 200–250 g and aging 8...

background: in this study, the presence of resistance to diclazuril, amprolium+ethopabate and salinomycin, representing some of the commonest anticoccidials in iran’s poultry industry, against three mixed eimeria field isolates were investigated. methods: three eimeria field isolates, collected from typical broiler farms in iran, were propagated once, inoculated to 480 broilers, comprising 30 c...

background and objectives: the prevalence of multidrug resistant pseudomonas aeruginosa is the main reason of new drugs resurgence such as colistin. the main objectives of this study were to determine the antibiotic resistance pattern and the rate of colistin resistance along with its correlation with overexpression of mexab-oprm and mexxy-oprm efflux pumps among p. aeruginosa isolates. materia...

context turmeric is obtained from the plant curcuma longa l; its major constituent, curcumin, is a polyphenol with multiple effects which can modulate some signaling pathways. evidence acquisition insulin resistance is a major risk factor for chronic diseases such as type 2 diabetes, atherosclerotic, metabolic syndrome and cardiovascular disease. in addition, insulin resistance in peripheral ti...

INTRODUCTION Epidermal growth factor receptor (EGFR) is an attractive drug target in lung cancer, with several anti-EGFR antibodies and small-molecule inhibitors showing efficacy in lung cancer patients. Patients, however, may develop resistance to EGFR inhibitors. We demonstrated previously that hepatocyte growth factor (HGF) induced resistance to EGFR tyrosine kinase inhibitors in lung cancer...

PURPOSE Tumor microenvironment confers drug resistance to kinase inhibitors by increasing RKT ligand levels that result in the activation of cell-survival signaling including PI3K and MAPK signals. We assessed whether HSC-LX2 coculture conferred sorafenib resistance in Huh7 and revealed the mechanism underlying the drug resistance. EXPERIMENTAL DESIGN The effect of LX2 on sorafenib resistance...