Disrupted sleep is probably the most common complaint of parents with a new baby. Night waking increases in the second half of the first year of infant life and is more pronounced for breastfed infants. Sleep-related phenotypes of infants with Prader-Willi and Angelman syndromes suggest that imprinted genes of paternal origin promote greater wakefulness whereas imprinted genes of maternal origi...

it is postulated that ritalin may adversely affect sleep, appetite, weight and growth of some children with adhd. therefore, we aimed to evaluate melatonin supplementation effects on dietary intake, growth and development of children with adhd treated with ritalin through circadian cycle modification and appetite mechanisms.after obtaining consent from parents, 50 children aged 7-12 with combin...

BACKGROUND Reductions in sudden infant death syndrome (SIDS) are commonly attributed to modifications in infant sleep environments. Approaches to diagnosis in sudden infant death, death scene investigations, the prevalence of intrinsic risk factors for SIDS, and the potential influence of treatment-related factors on infant vulnerability have also changed. Understanding all contributory factors...

BACKGROUND AND OBJECTIVE Reports describing factors associated with sleep-related infant death rely on caregiver report or postmortem findings. We sought to determine the frequency of environmental risk factors by using nocturnal sleep videos of infants. METHODS Healthy, term newborns were recruited for a parent study examining the role of parenting in the development of nighttime infant slee...

0733 components not targeted by known kinase inhibitors. From the library of screened compounds, Shokat and colleagues identifi ed a molecule (hydroxy-PP) that, though structurally related to a known kinase inhibitor, induced morphological changes distinct from any known kinase inhibitor. What does hydroxy-PP target? An enzyme, called carbonyl reductase 1 (CBR1), that acts on xenobiotics like a...

OBJECTIVE To determine whether postnatal mother-infant sleep proximity affects breastfeeding initiation and infant safety. DESIGN Randomised non-blinded trial analysed by intention to treat. SETTING Postnatal wards of the Royal Victoria Hospital (RVI), Newcastle upon Tyne, UK. PARTICIPANTS 64 newly delivered mother-infant dyads with a prenatal intention to breastfeed (vaginal deliveries, ...

S leep position is an important safety issue for infants younger than 1 year. This is because sudden infant death syndrome (SIDS) is associated with infants sleeping on their tummies. Sudden infant death syndrome is the leading cause of death for infants younger than 1 year. It most commonly occurs in babies between the ages of 2 and 4 months. Despite more than 15 years of the “back to sleep” e...

Positioning an infant to sleep on the back (supine positioning) has been recommended by the American Academy of Pediatrics (AAP) since 1992 to reduce the risk of Sudden Infant Death Syndrome (SIDS).1 SIDS is defined as a sudden death before 1 year of age that cannot be explained despite a thorough case investigation, including a complete autopsy, death scene examination, and review of the clini...