INTRODUCTION AND OBJECTIVES In the absence of right ventricular hypertrophy or bundle-branch block, a prominent R wave in V(1) or V(2) is considered to reflect a lateral myocardial infarction. We investigated the differences in infarct location, size and transmural extent between patients with prominent R wave in V(1) and those with prominent R wave in V(2). METHODS We studied 50 patients wit...

The prototype radionuclide imaging technique for detecting acute myocardial infarction is technetium-99m stannous pyrophosphate ( mTc PPi) myocardial scintigraphy. Today, this imaging assessment is commonly made with single photon emission cornputed tomography (SPEGT) that allows the detection of infarcts as small as 1 g, localization of the site of infarction, and accurate measurements of the ...

Myocardial infarction, commonly known as heart attack, is caused by reduced blood supply and damages the heart muscle because of a lack of oxygen. Myocardial infarction initiates a cascade of biochemical and mechanical events. In the early stages, cardiomyocytes death, wall thinning, collagen degradation, and ventricular dilation are the immediate consequences of myocardial infarction. In the l...

Background Patients with dysglycemia at the time of ST-elevation myocardial infarction (STEMI) have a worse prognosis. The reasons for this are not entirely clear. Admission hyperglycemia has been associated with larger infarct size. The aims of this study were to examine the relation of acute and chronic glycemic state to myocardial scar and salvage characteristics in patients with reperfused ...

Methods and Results: When injected into the border zone of mice after acute myocardial infarction, Shhmodified CD34 cells (CD34) protected against ventricular dilation and cardiac functional declines associated with acute myocardial infarction. Treatment with CD34 also reduced infarct size and increased border zone capillary density compared with unmodified CD34 cells or cells transfected with ...

In order to evaluate the usefulness of thallium-201 (201TI) myocardial scintigraphy in delineating the location and size of prior myocardial infarction, 32 patients were evaluated at a mean of 7 + 2 months after infarction with a 12-lead ECG, resting 201Tl myocardial scintigram, biplane left ventriculogram and coronary angiograms. From the left ventriculogram, asynergy was quantified as percent...

Men who had been in hospital for myocardial infarction (MI) were compared with other male patients in an attempt to provide evidence on the hypothesis linking MI with poverty in childhood followed by relative affluence. In each of three social class groupings MI patients came from larger families than controls, and a higher proportion of their fathers had been unemployed for more than a year du...

BACKGROUND The circadian clock influences a number of cardiovascular (patho)physiological processes including the incidence of acute myocardial infarction. A circadian variation in infarct size has recently been shown in rodents, but there is no clinical evidence of this finding. OBJECTIVE To determine the impact of time-of-day onset of ST segment elevation myocardial infarction (STEMI) on in...

BACKGROUND Erythropoietin improves myocardial function in experimental models of myocardial infarction. The aim of the present study was to determine the value of erythropoietin in patients with acute ST-elevation myocardial infarction. METHODS AND RESULTS This randomized, double-blind study included 138 patients admitted with acute ST-elevation myocardial infarction and treated with primary ...

OBJECTIVE We recently demonstrated that transfusion of anemic animals up to 100 g/L hemoglobin with fresh blood protects the heart from ischemic injuries following myocardial infarction. Erythropoietin has cardioprotective effects independent of its erythropoietic activity. The objective of this study was to compare the cardioprotective effects of erythropoietin treatment to fresh-blood transfu...