Themost significant consequences of diabetic foot problems are ulcerations and amputations. ▶ Between 0.8 and 10% of all people with diabetes mellitus suffer from a foot ulcer. ▶ The annual rate of new diabetic foot cases is between 2.2 and 5.9 %. ▶ Germany is in the upper range of European countries with its rate of over 60000 amputations per year. Approximately 70% of all amputations are perf...

Background. Acral lentiginous melanoma (ALM) is a less-common form of melanoma in US, and it accounts for about 5% of all diagnosed melanomas in US. ALM is often overlooked until it is well advanced because of the lesion's location and its atypical appearance in the early stages. We present a case of ALM initially presented as a diabetic foot ulcer. Case Report. An 81-year-old man initially pre...

BACKGROUND Although debridement plays a significant role in the healing of diabetic foot ulcers, it may delay the healing process by damaging the granulation tissue. In this study, the efficacy of low-frequency ultrasound (LFU) in chronic wound healing in diabetic foot ulcers in patients with osteomyelitis was evaluated. METHODS This randomized clinical trial was conducted on 40 patients with...

OBJECTIVE Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer. In this study, the levels of lipid peroxides (LPO) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as well as the enzymatic antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in type 2 diabetes mellitus and diabetic foot ulcer ...

Background: Epidemiological characteristics of diabetic foot infection in our region are not clear. The purpose of this study was to determine the epidemiological features of diabetic foot infection in Babol, north of Iran. Methods: From March, 2005 to April, 2010, the epidemiological features of 450 cases of diabetic foot infection treated in two main teaching hospitals of Babol Medical Univer...

Background Diabetic patients at high risk for foot ulceration are often prescribed with custom-made therapeutic footwear. However, the evidence base to support the use of this footwear for ulcer prevention is still meagre [1]. The lack of offloading efficacy may play a role in this. In-shoe plantar pressure assessment is a valuable tool for evaluating footwear and guiding modifications to optim...

Introduction It has been demonstrated that plasma growth factor (PGF) responsible for proliferation of smooth muscle cells and fibroblasts significantly shortens treatment duration. Aim To determine the role of human growth factor in the healing of ulcers due to ischaemic diabetic foot syndrome (DFS) following previous angioplasty of the blood vessels of the lower leg and foot. Material and...

OBJECTIVE To compare risks of lower-extremity amputation between patients with Charcot arthropathy and those with diabetic foot ulcers. RESEARCH DESIGN AND METHODS A retrospective cohort of patients with incident Charcot arthropathy or diabetic foot ulcers in 2003 was followed for 5 years for any major and minor amputations in the lower extremities. RESULTS After a mean follow-up of 37 +/- ...

OBJECTIVE Painless mechanical trauma is believed to induce neuroosteoarthropathy at the neuropathic foot in diabetes (diabetic Charcot-foot). To investigate pressure nociception at the diabetic foot, we measured the pain perception thresholds for deep pressure (DPPPT, using Algometer II®) and cutaneous pressure (CPPPT, using calibrated monofilaments). METHODS In 24 diabetic patients with pain...

AIM To ascertain whether patients with type 2 diabetes are screened for diabetic foot, and to analyze the factors related to patients and centers associated to performance of such screening. MATERIAL AND METHODS A multicenter, epidemiological, cross-sectional study was conducted. The clinical records of 443 patients with type 2 diabetes monitored at Primary Care for at least 12 months were re...