Nostril stenosis is an uncommon deformity with a variable aetiology. It may be either congenital or acquired. The causes of the acquired form includes trauma, infection and iatrogenic injury to the vestibular skin. Previous surgery including septoplasty and rhinoplasty, overzealous use of chemicals, laser, electrocauterization and traumatic placement of nasal packing to control epistaxis contri...

Objective: To compare the safety and efficacy of microdebrider assisted partial inferior turbinectomy with the conventitional turbinectomy in patients with inferior turbinate hypertrophy. Design: Prospective randomized single blinded study. Setting: Academic Medical Center. Patients & Methods: Sixty patients with nasal obstruction and bilateral hypertrophied nasal turbinates that was refractory...

Fibrous dysplasia (FD) is a benign skeletal disorder in which abnormally overgrowing bony lesion replaces normal bone. FD can affect one bone (monostotic form) or multiple bones (polyostotic form). The craniofacial bones are involved in about 10% of subjects with monostotic FD. However, its occurrence in the sinonasal tract is very rare. We report a case of monostotic FD developed only in the i...

Epithelial-mesenchymal transition (EMT) is a biological process that allows epithelial cells to assume a mesenchymal cell phenotype. EMT is considered as a therapeutic target for several persistent inflammatory airway diseases related to tissue remodeling. Herein, we investigated the role of endoplasmic reticulum (ER) stress and c-Src in TGF-β1-induced EMT. A549 cells, primary nasal epithelial ...

BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease; the underlying mechanisms of cell signalling are not fully understood. STAT3 (signal transducer and activator of transcription 3) is a phosphokinase and a key signalling molecule implicated in cell cycle regulation. We studied the distribution and expression of STAT3 to examine the role of STAT3 in the pat...