Inflammation is a determinant of atherosclerotic plaque rupture, the event leading to most myocardial infarctions and strokes. Although conventional imaging techniques identify the site and severity of luminal stenosis, the inflammatory status of the plaque is not addressed. Positron emission tomography imaging of atherosclerosis using the metabolic marker fluorodeoxyglucose allows quantificati...

William S. Tillett (1930) discovered that C-Reactive Protein (CRP) is an acute-phase serum protein that reacts with the C polysaccharide of Pneumococcal cell wall. CRP is present in human serum and its level increases during systemic inflammation. Therefore, CRP represents a sensitive marker of systemic inflammation and tissue damage; precise determination of CRP levels has proven to be useful ...

Rheumatoid arthritis (RA) causes high rate of the mortality. Cardiovascular disease (CVD) is markedly elevated in RA partly due to accelerated atherosclerosis (AS) from chronic inflammation. Homocysteine’ elevation (Hcys) strongly related AS and CVD’s progression RA. Current study aims evaluates Hcys level status its relation with activity (DA) inflammation marker (CRP) Duhok patients. Sixty-fo...

Inflammation of the thyroid gland is referred to as thyroiditis and associated with inflammation. Recent studies found significant association between novel inflammatory metabolic markers, well C-reactive protein (CRP). CRP/lymphocyte count ratio (CLR) a marker that various conditions has not been studied in thyroiditis, yet. We aimed investigate CRP lymphocyte patients compare those healthy su...

Fraction of exhaled Nitric Oxide (FeNO) is a marker airway inflammation. We examined the main effects and interactions relative humidity (RH) air pollution on adolescents’ FeNO. Two thousand forty-two participants from 15-year follow-up German GINIplus LISA birth cohorts were included. Daily meteorological (maximum [Tmax], minimum [Tmin] mean [Tmean] temperatures RH) [Ozone (O3), nitrogen dioxi...

Background We previously reported that coronary distensibility can be measured non-invasively using 3T MRI and that distensibility is reduced in coronary artery disease (CAD) patients compared with healthy subjects. Because atherosclerotic vascular disease is an inflammatory process, we sought to test the hypothesis that coronary distensibility measured with MRI is associated with systemic infl...

We evaluated associations between levels of BDG and other biomarkers of inflammation in blood from 41 virologically suppressed persons with chronic HIV-infection. We found a significant correlation between BDG and neopterin levels (r=0.68), and trends to significance for correlations with other inflammation markers (tumor-necrosis-factor-α: r=0.30; interleukin-8: r=0.30; interleukin-6: r=0.28)....

Elevated neutrophil/lymphocyte ratio (NLR) has been reported as a sensitive marker for predicting poor prognosis in chronic inflammation-based diseases such stroke, heart failure, cancers, and diabetes, well acute inflammatory bacterial viral infections, including COVID-19. NLR is also known to increase with age considered be an aging marker. We conducted double-blind, placebo-controlled trial ...

AIM The aim of our study was to determine whether an inflammation-based prognostic score predicted tumor aggressiveness and disease-free survival (DFS). PATIENTS AND METHODS We retrospectively reviewed 197 patients with locally advanced gastric cancer. The preoperative inflammation-based score was calculated as follows: patients with elevated C-reactive protein (>0.5 mg/dl) and hypoalbuminemi...

Gastric cardia cancer (GCC) is a highly aggressive disease associated with chronic inflammation. To investigate the relationship between DNA damage response (DDR) and chronic inflammation, we collected 100 non-tumor gastric cardia specimens of Chaoshan littoral, a high-risk region for esophageal and gastric cardia cancer. A significantly higher proportion of severe chronic inflammation was foun...