Melatonin is a hormone that exhibits many bioactivities such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, neuroprotective, and anti-aging activity. In addition, melatonin has been used to strengthen the effect of drugs or agents for treatment in different disease models cancer, tumor, bacterial infection, autoimmune diseases, gastrointestinal diseases. According recent s...

Objective: The purpose of the research was to implement molecular docking simulation investigate anti-inflammatory capability against thioesterase-2, an essential component inflammatory reaction in humans. Methods: After obtaining three-dimensional structures arthritis ligand and thioesterase-2 protein from IUPHAR/BPS Guide PHARMACOLOGY, PUBCHEM, RCSB PDB databases server, ligands with suitable...

objective: pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. in this study the effects of carvacrol on serum levels of total protein (tp), phospholipase a2 (pla2) and histamine in sensitized guinea pigs was evaluated. materials and methods: sensitized guinea pigs were given drinking water alone (group s), drinking water containing three concentration...

Osteoarthritis is a substantial burden for patients with the disease. The known medications disease target mitigation of disease’s symptoms. So, drug development management osteoarthritis represents an important challenge in medical field. This work based on new benzofuran–pyrazole–pyridine-based compound 8 potential anti-inflammatory and anti-osteoarthritis properties. Microanalytical spectral...

Paracetamol is a commonly used NSAID (Non-steroidal anti-inflammatory agent) since its introduction by Von Mering in 1893. Its popularity is because of its long safety record and good efficacy in children and adults. Though it has been used for so many years, its mechanism of action is yet to be elucidated. NSAIDS inhibit prostaglandin synthesis by inhibiting COX-1(Cyclooxygenase-1) and COX-2(C...

We report here on the covalent conversion of the anti-inflammatory agent ketoprofen into self-assembling prodrugs that enable the effective purification of ketoprofen enantiomers, the improved selectivity and potency of ketoprofen, as well as the formation of one-component drug-bearing supramolecular hydrogels. We found that the ketoprofen hydrogelator could exhibit much-enhanced selectivity fo...

Paclitaxel is an anti-microtubule agent, most widely used chemotherapeutic agent for the treatment of malignant solid tumors. However, it associated with some severe side effects including painful neurotoxicity reporting neuropathic pain and sensory abnormalities by patients during after paclitaxel therapy. Peripheral neuropathy was induced administration (4 mg/kg on days 1, 3, 5, 7). In this s...

Radiotherapy can convert malignant cells into an in situ anticancer vaccine, but is often inadequate at generating sufficient pro-inflammatory signals to optimally activate innate and adaptive immune responses. Topical imiquimod is a powerful pro-inflammatory agent with clinical activity against superficial skin cancers. These two modalities appear to complement each other, hence achieving loca...

Abstract Acne vulgaris is a common disease of the pilosebaceous unit. Hyperseborrhea, follicular colonization by Cutibacterium acnes and complex inflammatory state are pathogenic factors acne vulgaris. In present study we investigated anti-acne efficacy Castanea crenata bur extract (CBE) in vitro searched active compound for mitigating hyperseborrhea. sebocytes, CBE inhibited sebum synthesis th...

OBJECTIVE To investigate differential diagnosis between intrahepatic cholangiocarcinoma (ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound (CEUS). METHODS ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging feat...