Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy...

post-traumatic stress disorder (ptsd) is an anxiety disorder that can typically occur after traumatic events in which the individual felt sever helplessness or horror. ptsd has a lifetime prevalence of 5–8% and women show higher prevalence than in compared with men. neuroinflammation is associated to anxiety and related disorders such as ptsd. it is an early, specialized immune reaction fallowi...

Neuroinflammation is recognised as one of the potential mechanisms mediating the onset of a broad range of psychiatric disorders and may contribute to nonresponsiveness to current therapies. Both preclinical and clinical studies have indicated that aberrant inflammatory responses can result in altered behavioral responses and cognitive deficits. In this review, we discuss the role of inflammati...

Hydrogen gas is a bioactive molecule that has a diversity of effects, including anti-apoptotic, anti-inflammatory and anti-oxidative properties; these overlap with the process of neuroprogression in major psychiatric disorders. Specifically, both bipolar disorder and schizophrenia are associated with increased oxidative and inflammatory stress. Moreover, lithium which is commonly administered f...

Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enhanced by systemic inflammation, such as that due to cardiovascular disease and...

Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or autoimmune disorders. These include development, reproduction, aging, tumor development and tumor rejection, cardiovascular pathologies, metabolic ...

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system that inflammation, demyelination, oligodendrocyte loss, gliosis, axonal injury and neurodegeneration are the main histopathological hallmarks of the disease. Although MS was classically thought as a demyelinating disease, but axonal injury occurs commonly in acute inflammatory lesions. In MS mi...

Mental disorders such as depression and anxiety inflict significant burdens on individuals society. Commonly prescribed treatments often involve cognitive therapy medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD its key metabolite, β-hydroxybutyrate (BHB), have been hypothesized alleviate ...

The two immunoinflammatory disorders, rheumatoid arthritis (RA) and Periodontitis (PD) are characterized by synovitis, joint damage, alveolar bone degradation, triggered certain inflammatory mediators leukocyte invasion, respectively. Rheumatoid is an infectious disorder which attacks changed self-epitopes thus affects 1% of the human population, whereas 11% worldwide population aged afflicted ...

SUMMARY COVID-19 infection is more severe in patients with type 2 diabetes mellitus (DM2). The severity of this viral associated an intense inflammatory activity. DM2 a disease that also determines greater degree systemic inflammation. This due to hyperglycemia, the higher prevalence sleep disorders and low levels melatonin, substance anti-inflammatory actions, these patients. In article, we su...