نتایج جستجو برای: ingenol mebutate
تعداد نتایج: 232 فیلتر نتایج به سال:
Alzheimer's disease is a neurodegenerative disease that was conventionally thought to be related to the sedimentation of beta-amyloids, but drugs designed according to this hypothesis have generally failed. That FKBP52 can reduce the accumulation of tau proteins, and that Tacrolimus can reduce the pathological changes of tau proteins are new directions away from the long held amyloid-beta-centr...
The reaction of benzyl-ammonium tetra-fluoro-borate and 18-crown-6 in a methano-lic solution yields the title compound, C(7)H(10)N(+)·BF(4) (-)·C(12)H(24)O(6)O6, which displays a supra-molecular structure. The -NH(3) (+) substituent of the benzyl-ammonium cation forms a 1:1 supra-molecular rotator-stator structure by N-H⋯O hydrogen-bonding inter-actions.
Tritium-labeling o f the ingenol monoester 3-O-tetradecanoylingenol (3-TI), the prototype tumor promoter o f the ingenane type diterpene esters, is described. The preparation starts with oxidation o f 3-TI by manganese dioxide to yield 3-TI-20-aldehyde which is reduced by [3H]sodium borohydride in the presence o f equimolar amounts o f cerium trichloride hexahydrate to give [20-3H]-3-TI. The la...
Myriad interventions are available for the treatment of actinic keratosis located on face or scalp. However, lesions outside head and neck have received little attention until now. We aimed to synthesize current knowledge in nonscalp nonface localizations. Randomized controlled trials reporting data these localizations were searched MEDLINE, Embase, The Cochrane Library CENTRAL, as well pertine...
Bioassay-guided fractionation of an EtOAc extract of the stem wood of Euphorbia quinquecostata using a phorbol dibutyrate receptor-binding assay system as a monitor yielded four inhibitory isolates (1-4), inclusive of one new compound, 17-hydroxyingenol 20-hexadecanoate (1), and three previously known compounds, ingenol 20-hexadecanoate (2), ent-16 alpha,17-dihydroxyatisan-3-one (3), and ent-3 ...
The persistence of latently infected cells in patients under combinatory antiretroviral therapy (cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are needed and activation of viral gene expression in latently infected cells is one promising strategy. Bromodomain and Extraterminal (BET) bromodomain inhibitors (BETi) are compounds able to reactivate latent provir...
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