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This report presents a new modification of the isoniazid (INH) structure linked with different anilines via a carbonyl group obtained by two synthetic procedures and with N-substituted 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-amines prepared by their cyclisation. All synthesised derivatives were characterised by IR, NMR, MS and elemental analyses and were evaluated in vitro for their antimycobacter...
The aim of this study was to use DNA sequencing analysis to analyze the mutations in the most commonly targeted genes (katG, inhA, rpoB, rpsL) in isoniazid (INH)-, rifampin (RIF)- and streptomycin (SM)-resistant Mycobacterium tuberculosis strains obtained from subjects in Duzce, Turkey. Four isolates were found to be INH-resistant, 3 were RIF-resistant and 5 were SM-resistant, out of a total of...
20 An outbreak of multi-drug resistant tuberculosis has been reported on Daru Island, Papua New 21 Guinea. The Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual 22 of drug resistance mutations have not been described. We analyzed 100 isolates using whole 23 genome sequencing and found 95 belonged to a single modern Beijing strain cluster. Molecular 24 dating sugg...
We standardized and assessed the performance of an in-house microtiter assay for determining the susceptibilities of Mycobacterium tuberculosis clinical isolates to isoniazid based on mycobacteriophage amplification technology. Seventy isolates (43 resistant and 27 sensitive according to the BACTEC 460 radiometric method and MIC determination) were studied. The isoniazid resistance molecular me...
Molecular dynamics (MD) simulations of 12 aqueous systems of the NADH-dependent enoyl-ACP reductase from Mycobacterium tuberculosis (InhA) were carried out for up to 20-40 ns using the GROMACS 4.5 package. Simulations of the holoenzyme, holoenzyme-substrate, and 10 holoenzyme-inhibitor complexes were conducted in order to gain more insight about the secondary structure motifs of the InhA substr...
Source/description: Ovulation rate is an important trait influencing litter size in swine and contributes to reproductive success in pig production. Several quantitative trait loci (QTL) for ovulation rate have been identified in the pig. One region on chromosome 15 was associated with ovulation rate in a Meishan cross and in lines selected for components of litter size. The porcine inhibin a-s...
Dae-Hyun Kim, Sang-Bae Ko, Jae-Kwan Cha, Keun-Sik Hong, Kyung-Ho Yu, Ji Hoe Heo, Sun-Uck Kwon, Hee-Joon Bae, Byung-Chul Lee, Byung-Woo Yoon, Jeong Eun Kim, Hyun-Seung Kang, Dae-Hee Seo, Sukh-Que Park, Seung Hun Sheen, Hyun Sun Park, Sung Don Kang, Jae Min Kim, Chang Wan Oh, In Sung Park, Joung-Ho Rha Department of Neurology, Dong-A University College of Medicine, Busan, Korea Department of Neur...
The aim of the present study was to evaluate inhibin secretion in rats with autoimmune orchitis. As we have previously described, experimental autoimmune orchitis (EAO) induced in rats by active immunization with testis homogenate and adjuvants is characterized by an interstitial mononuclear cell infiltrate and sloughing of the germinal epithelium. At 120 days after the first immunization 60% o...
Introduction Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, has been a global threat to human beings for several decades. Treating become more difficult as prevalence drug-resistant increased globally. Evidence suggests that comprehensive landscape resistance mechanisms in MTB is ambiguous. More importantly, little known regarding series events connected before exposure ...
Infectious diseases pose a potential threat and are responsible for killing more people globally than any other single cause. For six decades, antibiotics have been a bulwark against bacterial infectious diseases. This bulwark is failing due to the appearance of resistant bacterial strains. The biosynthesis pathway of fatty acids in bacteria represents a validated target for antibacterial drug ...
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