Previous studies have suggested that schizophrenia patients do not utilize contextual information efficiently to modulate attentional performance. The goal of the current study was to compare the utilization of context in modulating responses to irrelevant information on the Stroop task between a group of schizophrenia outpatients and matched controls. A single-trial version of the Stroop task ...

The gate control theory proposed that the nociceptive sensory information transmitted to the brain relies on an interplay between the inputs from nociceptive and non-nociceptive primary afferent fibers. Both inputs are normally under strong inhibitory control in the spinal cord. Under healthy conditions, presynaptic inhibition activated by non-nociceptive fibers modulates the afferent input fro...

Inhibitory interneurons across diverse brain regions commonly exhibit spontaneous spiking activity, even in the absence of external stimuli. It is not well understood how stimulus-evoked inhibition can be distinguished from background inhibition arising from spontaneous firing. We found that noradrenaline simultaneously reduced spontaneous inhibitory inputs and enhanced evoked inhibitory curren...

Shifting and inhibition are executive cognitive functions responding selectively to stimuli, so as to switch from one activity to a more compelling one or to inhibit inappropriate urges and preserve focus on the current task. In an autonomous system these cognitive skills are crucial to assess a well-regulated reactive behavior, which is of particular relevance in critical circumstances. In thi...

The importance of the renin angiotensin system (RAS) in blood pressure and electrolyte regulation has been well established. High RAS activity results in over-activation of the angiotensin AT1-receptor by its substrate, angiotensin II (AII), leading to increases in BP and direct growth-promoting effects on tissues that result in end-organ damage. The antihypertensive therapies, such as ACE inhi...

background and aims: rubella is a contagious viral disease mostly with mild clinical symptoms and often remains undiagnosed. rubella infection may adversely affect pregnancy, especially in the first trimester and this mother to child transmission can cause congenital rubella and may be lead to permanent disability and mortality in children. effective rubella vaccine should be prepared using sui...

background: pandemic flu had at least two waves in iran. knowing how many of the general population were already exposed to this infection has a major impact on na-tional preventive measures. as of december 30, 2009, a total of 3672 confirmed cases of human infection with a novel influenza a (2009 h1n1) virus had been reported in iran with 140 deaths. objective: in this study we aim to measure,...

objective: tyrosinase as the key enzyme in melanin biosynthesis, involves in determining the color of mammalian skin and hair. a variety of dermatological disorders, come up from an unnecessary level of epidermal pigmentation. plants are low-cost and rich sources of active compounds.  methods: more than seventy native plants collected from the central region of kurdistan province collected. inh...

alpha-amylase is widely used as an industrial enzyme, and a therapeutic target for which inhibitors are designed. organic solvents are used to dissolve various compounds that would be studied as moderators of alpha-amylases, but they could themselves affect enzyme activity and stability. methanol, ethanol and propanol are simple alcohols that may be commonly used to this end, and their effect h...