Side population (SP) and ABC transporter expression enrich for stem cells in numerous tissues. We explored if this phenotype characterised human bladder cancer stem cells (CSCs) and attempted to identify regulatory mechanisms. Focusing on non-muscle invasive bladder cancer (NMIBC), multiple human cell lines were used to characterise SP and ABC transporter expression. In vitro and in vivo phenot...

G protein-coupled receptor kinase 2 (GRK2) participates together with β-arrestins in the regulation of G protein-coupled receptor signaling, but emerging evidence suggests that GRK2 can interact with a growing number of proteins involved in signaling mediated by other membrane receptor families under various pathologic conditions. We tested the hypothesis that GRK2 may be an important contribut...

The effects of stress (threat of shock) on GSR nonspecific responses were evaluated for Ss who differed in transitory anxiety as measured by the Affect Adjective Check List (AACL). 52 Ss were equally divided among 4 groups: Hi AACL Stress, Lo AACL Stress, Hi AACL Nonstress, and Lo AACL Nonstress. First, all Ss rested; then both Stress groups were threatened with shock, while both Nonstress grou...

Much has been learned about calculation, commodification and marketization from the social studies of markets and finance. But what of capitalization? What is distinctive about this mode of valuation and the reality it impels? What does it mean to live under the ‘asset condition’? In Capitalization: A Cultural Guide, Fabian Muniesa and his colleagues at the Centre de Sociologie de l’Innovation ...

Classification permeates us: our being and our world. This paper seeks to extend the information systems literature on classification by suggesting classification as a quest, involving man, in a process comprised of both finding and producing truth. Drawing on Martin Heidegger’s etymological enquiry, classification is reinterpreted as a dynamic movement towards order. The essence of technology ...

abstract: measles remains one of the leading causes of childhood morbidity and mortality in developing countries and is still a major public health concern in developed countries. although live attenuated vaccine is used throughout the world, out breaks of disease still occur in many countries including iran. understanding measles outbreaks that occur after the initiation of measles elimination...

Introduction Though the human fetus is exposed to placentally derived human chorionic gonadotropin (hCG) throughout gestation, the role of hCG on the fetal brain is unknown. Review of the available literature appears to indicate that groups of women with higher mean levels of hCG during pregnancy tend to have offspring with lower cerebral palsy (CP) risk. Given that newborn cerebral injury ofte...

Fowlpox (FP) is a serious disease in chickens caused by Fowlpox virus (FPV). One method currently used to control FPV is vaccination followed by confirmation that antibody titres are protective using the indirect haemagglutination assay (IHA). The direct haemagglutination inhibition (HI) assay is not done because most FPV strains do not agglutinate chicken red blood cells (RBCs). A novel FPV st...

The mechanisms underlying cytoplasmic pH (pHi) regulation in rat thymic lymphocytes were studied using trapped fluorescein derivatives as pHi indicators. Cells that were acid-loaded with nigericin in choline+ media recovered normal pHi upon addition of extracellular Na+ (Nao+). The cytoplasmic alkalinization was accompanied by medium acidification and an increase in cellular Na+ content and was...