AIM The purpose of the study was to analyze the cases discussed in High Health Council (HHC) and to determine the solutions for the problems on gluteal intramuscular injection (IMI) applications. MATERIAL AND METHODS In the 9 year period, the cases of IMI related sciatic nerve injury (SNI) sending to take an opinion the Turkey HHC were reviewed. Cases were analyzed in demographic information,...

Inhibition of β-site APP cleaving enzyme 1 (BACE1) is being pursued as a therapeutic target for treating patients with Alzheimer's disease because BACE1 is the sole β-secretase for generating β-amyloid peptide. Knowledge regarding the other cellular functions of BACE1 is therefore critical for the safe use of BACE1 inhibitors in human patients. BACE1 deficiency in mice causes hypomyelination du...

Transplantation of Schwann cells (SCs) can promote axonal regeneration and formation of the myelin sheath, reduce inflammation, and promote repair to the damaged nerve. Our previous studies have shown that transplantation of free or micro-encapsulated olfactory ensheathing cells can relieve neuropathic pain. There are no related reports regarding whether the transplantation of micro-encapsulate...

Clinical use of neurotoxins from Clostridium botulinum is well established and is continuously expanding, including in treatment of pain conditions. Background: The serotype A (BoNT/A) has been widely investigated, and current data demonstrate that it induces analgesia and modulates nociceptive processing initiated by inflammation or nerve injury. Given that data concerning the serotype B (BoNT...

Our previous studies have shown that median and ulnar nerve lesion induced calbindin (CB) immunoreactivity in some injured motoneurons in developing rats. Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of neuronal isoform of nitric oxide synthase (nNOS). The present study investigated whether expression of CB and nicotinomid adenin dinucleot...

BACKGROUND Bogijetong decoction (BGJTD) is a herbal drug formulation used in the traditional Asian medicine to treat neuropathic insults associated with diabetes and anticancer therapy. To understand the biological basis of BGJTD on protective effects against neuropathy, we investigated physiological and biochemical responses of the sciatic nerves deranged by taxol injection or crush injury in ...

Background. Peripheral nerve injury-evoked neuropathic pain still remains a therapeutic challenge. Recent studies support the notion that progesterone, a neuroactive steroid, may offer a promising perspective in pain modulation. Objectives. Evaluate the effect of progesterone administration on the development of neuropathic pain-associated allodynia and on the spinal expression of N-Methyl-D-As...

Sciatic notch tumours of the intra-pelvic variety are rare lesions and commonly arise from sciatic nerve. These usually benign neurogenic most common them is schwannoma. Conventional laparotomy techniques have associated surgical morbidity significant blood loss. The advent robotic systems refinement in robotic-assisted to access deep lying pre-sacral has offered a novel way surgically handle s...

background: the standard method for repair of an injured peripheal nerve is epineural repair with separate sutures. herein we describe a method in which the nerve is sutured with continous sutures. in fact this method has not been utilized for nerve repair previously and our purpose was to compare it to the standard method. if it proved to be successful it would replace the standard method in c...

Background: Many people suffer from nerve injury. The time consuming nature of the treatments makes the condition worse. Therefore, finding a way to accelerate the process of nerve repair is very important.Objective: To determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration.Methods: The experimental model included crushed rat’s sciatic nerve. 40 rats w...