Infrared neural stimulation (INS) has been proposed as a novel method for neural stimulation. In order for INS to translate to clinical use, which would involve the use of implanted devices over years or decades, the efficacy and safety of chronic INS needs to be determined. We examined a population of cats that were chronically implanted with an optical fiber to stimulate the cochlea with infr...

Aiming to improve positioning precision of the GPS/INS integrated navigation system during GPS outages, a novel model combined with strong tracking Kalman filter (STKF) and wavelet neural network (WNN) algorithms for INS errors compensation is proposed and tested. STKF is used to estimate INS errors as a replacement of Kalman filter (KF), and WNN is applied to establish a highly accurate model ...

To study the contribution of primate cervical interneurons (INs) to preparation and execution of normal voluntary hand movement we investigated their activity and correlational linkages to muscles in monkeys performing tracking tasks. During ramp-and-hold flexion-extension torques about the wrist most task-related spinal INs exhibited some activity during both flexion and extension, in unexpect...

Dionysios Perdikis, Aix-Marseille Université (AMU), Inserm, Institut de Neurosciences des Systèmes (INS), UMR_S 1106, 13385, Marseille, France, [email protected], Raoul Huys, AMU, Inserm, INS, UMR_S 1106, 13385, Marseille, France, [email protected], Rita Sleimen-Malkoun AMU, Inserm, INS, UMR_S 1106, 13385, Marseille, France, [email protected], Jean Jacques Tempr...

A Kalman filter (KF) enhanced by the Gaussian process regression (GPR) technique is suggested to bridge GPS-outages in navigation solutions where inertial navigation systems (INS) and GPS are integrated. A KF utilises linearised dynamic models. If a low-cost MEMS-based INS with complex stochastic nonlinearity is considered, performance degrades significantly during short periods of GPSoutages o...

Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type, and one widely recognized goal is to make pancreatic β cells. To this end, comparisons between differentiated cell types produced in vitro and their in vivo counterparts are essential to validate hPSC-derived cells. Genome-wide transcriptional analysis of sorted insulin-expressing (INS(+)) cells derived fro...

OBJECTIVE Low-income outpatients with scheduled appointments ("scheduled patients") were compared with those who sought treatment without appointments ("walk-ins"). METHOD The charts of scheduled patients and walk-ins at an outpatient mental health clinic serving a low-income group were reviewed to determine sociodemographic and clinical characteristics and patients' pathways to treatment. ...

AIMS Insulin (Ins) resistance (IRES) associates to increased cardiovascular risk as observed in metabolic syndrome. Chronic stimulation of beta-adrenergic receptors (betaAR) due to exaggerated sympathetic nervous system activity is involved in the pathogenesis of IRES. The cellular levels of G protein coupled receptor kinase 2 (GRK2) increase during chronic betaAR stimulation, leading to betaAR...

Using immortalized [3H]inositol-labelled S3 cells, we demonstrated in the present study that various elements of the inositol phosphate signalling cascade are recruited by a Drosophila homologue from a cytokine family of so-called GBPs (growth-blocking peptides). HPLC analysis revealed that dGBP (Drosophila GBP) elevated Ins(1,4,5)P3 levels 9-fold. By using fluorescent Ca2+ probes, we determine...

The role of Ins(1,4,5)P3 in receptor-induced Ca2+ mobilization in pituitary cells was studied at the single-cell level. Experimental strategies were developed which allowed a comparative analysis of the effects of Ins(1,4,5)P3 with those of receptor activation under identical conditions. These include microfluorimetry as well as a novel technique which permits the controlled and rapid applicati...