Mutant form of H-Ras (Harvey-Ras) proteins are found in almost 10%-25% of human tumours. Mutational activation transforms it into an oncogenic form, which results in the loss of intrinsic GTPase function and therefore the protein is constitutively in the active, GTP-bound state and is continuously sending signals for cell growth and proliferation. In the present insilico study, the inhibitory e...

The Tuberculosis is the classical human mycobacterial disease, caused by Mycobacterium Tuberculosis. Mycobacterium tuberculosis is a facultative intracellular pathogen that has evolved the ability to survive and multiply within human macrophages. These bacteria comprise of significant proteins, which involve in the pathogenesis and regulation of cell activity. Thus there arises the need to unde...

Blood glucose management systems are an important class of Medical Cyber-Physical Systems that provide vital everyday decision support service to diabetics. An artificial pancreas, which integrates a continuous glucose monitor, a wearable insulin pump, and control algorithms running on embedded computing devices, can significantly improve the quality of life for millions of Type 1 diabetics. A ...

To develop a lead anti-diabetic compound, a series of 21 novel quinazoline derivatives have been synthesized and screened against alpha Glucosidase. The binding mode of the compounds at the active site of alpha Glucosidase was explored using Glide docking method. The binding model suggests one to four hydrogen bonding interactions between quinazoline derivatives and alpha-glucosidase. 6-Bromo-2...

The Immune System is, together with Central Nervous System, one of the most important and complex unit of our organism. Despite great advances in recent years that shed light on its understanding and in the unraveling of key mechanisms behind its functions, there are still many areas of the Immune System that remain object of active research. The development of in-silico models, bridged with pr...

Potential photoactivation of certain pharmaceuticals, cosmetic ingredients and natural products by sunlight (e.g., phenothiazines, arylsulfonamides, or coumarins) has to be considered early on in development in order to avoid serious adverse effects (for example phototoxic or photoallergic reactions). Current clinical trial registration guidelines (FDA May 2003 [1], EMEA Dec. 2002 [2]) recommen...

Title of thesis: CLOSED-LOOP FLUID RESUSCITATION: INSILICO STUDY Jonathan Cary Lucas V, Master of Science, 2015 Thesis directed by: Dr. Jin-Oh Hahn Department of Mechanical Engineering This thesis validates a control-oriented model of human circulatory dynamics associated with hemorrhage and fluid resuscitation, uses this model to design a series of closed-loop controllers for fluid resuscitati...

Objective: The objective is to distinguish the gene nomenclature of 36 types of spinocerebellar ataxia (SCA) and to find the non-synonymous singlenucleotide polymorphism (nsSNP) which is main target for spinocerebellar ataxia type 1 (SCA1). Method: The gene nomenclatures of spinocerebellar ataxias (SCAs) were collected from Entrez gene on NCBI website. SCA1 gene single nucleotide polymorphisms ...