Maintaining genomic stability in the face of replication and recombination requires a huge variety of different damage response proteins. A cell’s ability to decide when and where to deploy this DNA repair kit is critical to prevent tumor development. This issue’s Select highlights recent studies that help to explain how these difficult decisions are made and reveals that some surprising cellul...

Triplet-repeat expansions cause several inherited human diseases. Expanded triplet-repeats are unstable in somatic cells, and tissue-specific somatic instability contributes to disease pathogenesis. In mammalian cells instability of triplet-repeats is dependent on the location of the origin of replication relative to the repeat tract, supporting the 'fork-shift' model of repeat instability. Dis...

Power system blackouts have become a serious problem for electric utilities especially in recent years. Different forms of system instability have emerged in recent blackouts, such as voltage instability and frequency instability. To counteract each form of system instability, special algorithms have been designed in the protection system, e.g. Under Frequency Load Shedding (UFLS) and Under Vol...

purpose: to evaluate and compare tear secretion and tear film instability following laser in situ keratomileusis (lasik) and laser assisted subepithelial keratectomy (lasek). methods: in a randomized clinical trial, 30 eyes of 15 patients underwent lasik and 30 eyes of 15 patients underwent lasek to correct myopia. tear secretion and tear film instability were tested preoperatively, 2 and 6 wee...

every year, a considerable portion of the national budget specifies to reconstruct the properties which have been destroyed during natural disasters in iran. recognition of vulnerable sites to natural disasters can reduce the probable damages. the most important point in designing railway tracks is to join stations in the least possible time. so, the railway track is meant to cross lots of vall...

in this study to determine whether spine stiffness is predictive of clinical results after lumbar spinal fusion for spinal stenosis, a total of 78 patients were measured intraoperatively with kocher clamp manual distraction technique to determine motion segment stiffness then spinal fusion was performed for any loose segment. ‎statistical analysis revealed that stiffness measurement correlate w...

in this article, vibration analysis of an euler-bernoulli beam resting on a pasternak-type foundation is studied. the governing equation is solved by using a spectral finite element model (sfem). the solution involves calculating wave and time responses of the beam. the fast fourier transform function is used for temporal discretization of the governing partial differential equation into a set ...

This paper argues that both Keynes and Minsky held a concept of financial instability which may be properly understood only in terms of structural instability, and not –as is usual-in terms of the traditional concept of economic instability, i.e. dynamic instability. Keynes is quite explicit in denying that the dynamic instability of a monetary economy is a particularly serious problem; on the ...

Recurrent patellar instability can result from osseous abnormalities, such as patella alta, a distance of >20 mm between the tibial tubercle and the trochlear groove, and trochlear dysplasia, or it can result from soft-tissue abnormalities, such as a torn medial patellofemoral ligament or a weakened vastus medialis obliquus. Nonoperative treatment includes physical therapy, focusing on strength...