context since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on which drug should be preferred as add-on therapy in patients failing to metformin. at the moment, there is no real consensus. the aim of the p...

Neutrosophic Genetics is the study of genetics using neutrosophic logic, set, probability, statistics, measurement, and other tools procedures. In this paper, based on Theory Evolution (that includes degrees Evolution, Neutrality (or Indeterminacy), Involution) – as an extension Darwin’s we show applicability neutrosophy in genetics, present within frame following concepts: mutation, speciation...

diabetes mellitus is a group of metabolic diseases. insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. adiponectin as a 244 amino acid protein is exclusively expressed...

molecular genetics of colorectal cancer

Although several epidemiologic studies reported plausible and potentially causal associations between oral infections and cardiometabolic diseases (CMDs), controversy still lingers. This might be due to unrecognized confounding from metabolic inflammation and genetics, both of which alter the immune responses of the host. Low-grade inflammation termed metainflammation is the hallmark of obesity...

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spherical equivalent (se) has not been linked to increased cardiovascular morbidity. methods: 132 hungarian twins (age 43.3±16.9 years) underwent refraction measurements (huvitz mrk-3100 premium autorefractokeratometer) and oscillometry (tensiomed arteriograph). results: heritability analysis indicated major role for genetic components in the presence of right and left se (82.7%, 95%ci, 62.9 to...

introduction: pathophysiology of cancer is based on genetic instabilities. this can explain recent important role of genetic studies in such diseases. defects can be large (on molecular scale) at the level of chromosomal or small in nucleotide level, which eventually causes to irreversible change in the cell. conventional technical methods in cancer genetics are generally based on molecular or ...

background: essential hypertension tends to a familial mode. its pattern of inheritance is heterogeneous, but the frequencies of different mode of inheritance vary in different populations. determining of the mode of inheritance in each family is the basic information that is needed for the risk estimation in those family members. determination of pattern of inheritance in families with at leas...