background: thioredoxin reductase 1 (txnrd1) and thioredoxin interacting protein (txnip) also known as thioredoxin binding protein 2 or vitamin d3-upregulated protein 1 are key players in oxidative stress control. thioredoxin (trx) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes. computational analyses of txnrd1, txnip and trx expressio...

We report a novel 3D structure-based method of predicting protein-protein (PP) interaction (PPI) partners. The method involves screening for pairs of tetrahedra representing interacting amino acids at the interface of the PP complex, with one tetrahedron on each protomer*. H-bonds and VDW interactions at the interface of the two interacting protein molecules in the complex are first determined,...

the gene tp53 (also known as protein 53 or tumor protein 53), encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. there are reports of nearly 250 independent germ line tp53 mutations in over 100 publications. the p53 protein has the structure of a transcription factor and, is made up of several domains. t...

We propose a domain-based classification method to predict protein-protein interactions using probabilities of putative interacting domain pairs derived from both experimentally-determined interacting protein pairs and carefully-chosen non-interacting protein pairs. Multi-species comparative results for protein interaction prediction show that such careful generation of biologically meaningful ...

Background: Alteration in the protein signatures of functionally immature testicular spermatozoa occurs during their journey through the epididymis. This leads to acquisition of sperm domain specific functions essential for successful fertilization. Epididymal sperm proteins are preferred targets for immunocontraception as well as in elucidating the causes of infertility. The Background of the ...

Salt stress severely limits soybean production worldwide. Calcineurin B-like protein-interacting protein kinases (CIPKs) play a pivotal role in plant’s adaption to salt stress. However, their biological roles remain poorly understood. Here, the GmCIPK2 expression was increased by NaCl and hydrogen peroxide (H2O2). GmCIPK2-overexpression Arabidopsis hairy roots displayed improved tolerance, wher...