Five synthetic combinatorial libraries of 2,080 components each were screened as mixtures for inhibition of DNA binding to two transcription factors. Rapid, solution-phase synthesis coupled to a gel-shift assay led to the identification of two compounds active at a 5- to 10-microM concentration level. The likely mode of inhibition is intercalation between DNA base pairs. The efficient deconvolu...

Nanosheets have attracted much interest because of their characteristic properties originating from anisotropic and flexible structures. Inorganic nanosheets are synthesized from precursor layered compounds through exfoliation in a liquid phase. In contrast, a versatile exfoliation approach has not been fully studied for organic layered compounds. Here we report two exfoliation approaches for o...

We study the formation of planar network nanostructures, which develop during metal deposition on initially smooth surfaces of layered compounds. Using in situ low-energy electron microscopy for dynamic observation and high-resolution transmission electron microscopy for structure analysis, we have observed the rapid formation of hexagonal networks of linear "nanofolds" with prismatic cavities ...

Two bisquinoline derivatives, N,N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N,N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay....

The intercalation compounds of layered dichalcogenides MX2 (M = transition metal, X = S, Se) with Lewis base guest molecules have received considerable attention due to their interesting physical properties and structural anisotropy [1]. The most simple molecule that is known to intercalate is the thermodynamically stable compound NH3; extensive work has been devoted to the characterization of ...

Muddy intercalation is one kind of rock’s secondary structural surface, where the failure of instability between strata occurred. Mechanical behaviour of muddy intercalation directly affects the stability of the rock mass. Starting from the micro-structure of Muddy intercalation, revealing its macroscopic mechanical characteristic is of great significance to the stability and optimization desig...