نتایج جستجو برای: interferon beta 1b

تعداد نتایج: 269096  

Journal: :iranian journal of neurology 0
payam khomand department of neurology, school of medicine, tohid hospital, kurdistan university of medical sciences, sanandaj, iran ghobad moradi social determinants of health research center, department of epidemiology and biostatistics, school of medicine, kurdistan university of medical sciences, sanandaj, iran setareh abtahi department of neurology, school of medicine, tohid hospital, kurdistan university of medical sciences, sanandaj, iran behrooz ahsan department of neurology, school of medicine, tohid hospital, kurdistan university of medical sciences, sanandaj, iran

abstract introduction:  this study was performed to compare the effects of low-dose interferon beta-1(cinnovex,30 mcg) and high-dose interferon beta-1(rebif,44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (mri) in patients with multiple sclerosis (ms). methods and materials: this historical cohort study, which was performed in 2014 in sanandaj (western p...

2018
Chang-Long He Ming Liu Zhao-Xia Tan Ya-Jun Hu Qiao-Yue Zhang Xue-Mei Kuang Wei-Long Kong Qing Mao

AIM To investigate the mechanism by which hepatitis C virus (HCV) core protein-induced miR-93-5p up-regulation regulates the interferon (IFN) signaling pathway. METHODS HCV-1b core protein was exogenously expressed in Huh7 cells using pcDNA3.1 (+) vector. The expression of miR-93-5p and interferon receptor 1 (IFNAR1) was measured using quantitative reverse transcription-polymerase chain react...

2000
David Parkin Ann Jacoby Paul McNamee Paul Miller Simon Thomas David Bates

Objective—To evaluate the cost-eVectiveness of interferon beta-1b (IFâ-1b) for relapsing-remitting multiple sclerosis (RRMS). Methods—Construction of a cost-eVectiveness model using published data on IFâ-1b eVectiveness and the natural history of RRMS, and new data on costs and quality of life (QoL) from a sample of 102 patients with RRMS and resident in northern England. Results—Poorer QoL was...

2014
Kassandra L Munger Karl Köchert Kelly C Simon Ludwig Kappos Chris H Polman Mark S Freedman Hans P Hartung David H Miller Xavier Montalbán Gilles Edan Frederik Barkhof Dirk Pleimes Rupert Sandbrink Alberto Ascherio Christoph Pohl

OBJECTIVE Some previous studies suggest modest to strong effects of 25-hydroxyvitamin D (25(OH)D) on multiple sclerosis (MS) activity. The objective of this study was to explore the mechanistic rationale that may explain potential clinical effects of 25(OH)D. METHODS This study measured serum 25(OH)D levels and global gene expression profiles over a course of up to 2 years in patients startin...

Journal: :Journal of neurology, neurosurgery, and psychiatry 2000
D Parkin A Jacoby P McNamee P Miller S Thomas D Bates

OBJECTIVE To evaluate the cost-effectiveness of interferon beta-1b (IFbeta-1b) for relapsing-remitting multiple sclerosis (RRMS). METHODS Construction of a cost-effectiveness model using published data on IFbeta-1b effectiveness and the natural history of RRMS, and new data on costs and quality of life (QoL) from a sample of 102 patients with RRMS and resident in northern England. RESULTS P...

Journal: :The Journal of Cell Biology 1994
F Balzac S F Retta A Albini A Melchiorri V E Koteliansky M Geuna L Silengo G Tarone

The integrin subunit beta 1B, a beta 1 isoform with a unique sequence at the cytoplasmic domain, forms heterodimers with integrin alpha chains and binds fibronectin, but it does not localize to focal adhesion sites (Balzac, F., A. Belkin, V. Koteliansky, Y. Balabanow, F. Altruda, L. Silengo, and G. Tarone. 1993. J. Cell Biol. 121:171-178). Here we analyze the functional properties of human beta...

Journal: :مجله علوم اعصاب شفای خاتم 0
ayda radfar student research committee, faculty of medicine, mashhad university of medical sciences, mashhad, iran

multiple sclerosis (ms) is an inflammatory disorder, in which neurons in central nervous system (cns) become demyelinated .ms is named for its formation of plaques due to sclerosis of myelin. variable degree of demyelination results in mild, mediate or severe symptomatic episodes of this disease. it is commonly characterized by recurrent relapses and often followed by severe neurological disabi...

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