conclusions erα expression in liver was inversely correlated with liver fibrosis among patients infected with chronic hcv genotype 1b. patients and methods all the consecutive patients who received the same standard treatment protocol for hcv genotype 1b were subdivided into two subgroups according to their fibrosis scores as fibrotic stages < 2 in mild fibrosis group and fibrotic stages ≥ 2 in...

UNLABELLED Since 1993 the Federal Drug Administration approved the use of immunomodulatory therapy in multiple sclerosis (MS), modifying the natural course of disease, as demonstrate our experience in treatment of MS patients at the MS Treatment Center (CATEM). OBJECTIVE To evaluate patient behavior using immunomodulatory therapy for a period of five years treatment. METHOD We selected 390 ...

Abstract Background and aims The burden of coronary atherosclerosis differs between men women. Beyond traditional cardiovascular risk factors, inflammatory biomarkers can influence plaque formation progression. We analyzed the gender difference on cytokines. Methods Coronary CT-Angiography was performed in 301 patients morphology quantitatively qualitatively assessed using semi-automated softwa...

Background: Brucella is a gram-negative bacterium, causing acute and chronic infection in humans and animals. Cell-mediated immunity is the main protective immune response against Brucella spp. Activation of macrophages by IFN-γ and generation of reactive oxygen intermediates and nitric oxide are the main immunologic mechanisms responsible for control of Brucella infection. Objective: To invest...

Certain properties of the antirickettsial activity and interferon in lymphokine preparations obtained from concanavalin A-stimulated mouse spleen cells were compared. Both the antirickettsial activity and interferon were relatively stable to heating at 56 degrees C, whereas both activities were destroyed by trypsin, by heating at 80 degrees C, or by exposure to pH 2 for 24 h. Both activities we...

The production of gamma interferon in acute acquired and congenital toxoplasmosis was studied. Gamma interferon was produced at significant titers (P less than 0.001) in the course of both congenital toxoplasmosis and acquired toxoplasmosis at an early stage of infection, when Toxoplasma gondii was multiplying. Its presence in fetal blood was correlated with the positive inoculation of fetal bl...

Theiler's virus causes a persistent infection and a demyelinating disease of mice which is a model for multiple sclerosis. Susceptibility to viral persistence maps to several loci, including the interferon gamma locus. Inactivating the gene coding for the interferon gamma receptor makes 129/Sv mice susceptible to persistent infection and clinical disease, whereas inactivating the interferon gam...

BACKGROUND In the randomized study of interferon beta-1b (IFN beta-1b) for multiple sclerosis (MS), it has usually been evaluated the simple annual relapse rate as the study endpoint. This study aimed to investigate the performance of various regression models using information regarding the time to each recurrent event and considering the MS specific data generation process, and to estimate th...

Atopic dermatitis is a common inflammatory skin condition that usually affects children. It is a chronic disease, with periods of remission and flare-ups, that adversely affects the quality of life of patients and their families. Aggressive therapy with emollients is an important intervention for patients with atopic dermatitis. Patients should avoid individual disease triggers and allergens. T...

Antiviral and macrophage-priming activities in the supernatant medium of a subclone of a concanavalin A-stimulated mouse T-cell hybridoma were investigated. The two activities were associated with a molecular weight of approximately 50,000 and could not be separated by various approaches. Both activities were eliminated by a highly specific neutralizing antibody against mouse interferon-gamma, ...